As the demand for therapeutic antibodies surges, so does the need for efficient and reliable development and manufacturing processes. At Creative Biolabs, we're proud to offer a comprehensive CDMO antibody production upstream process development service, tailored to meet the unique needs of our clients.

Understanding Upstream Process Development

Understanding Upstream Process Development The upstream process in antibody production involves all activities related to the generation and initial cultivation of the cells that produce antibodies. This phase encompasses cell line development, media optimization, control of culture conditions, and establishment of efficient feeding strategies. The goals of the upstream process are to optimize the yield and quality of the desired antibody product while reducing time and costs. Successful upstream development ensures robust, scalable, and cost-effective production by laying a strong foundation for downstream purification and processing. At Creative Biolabs, we specialize in designing and optimizing these upstream processes.

Our Upstream Process Development Services

At Creative Biolabs, we understand that every antibody project has unique requirements. Our team of experienced scientists is dedicated to tailoring the upstream process to align with specific project goals, ensuring optimized productivity and quality. We provide flexible and comprehensive services, from small-scale research productions to large-scale industrial operations.

The upstream development process begins with thorough cell line development, where we use advanced genetic engineering techniques to create stable, high-producing cell lines. Next, our media optimization phase employs high-throughput screening techniques to select the best feeding strategies and formulations, ensuring maximum cell viability and productivity. Following this, we conduct small-scale bioreactor studies to refine growth conditions and optimize yield. Finally, the optimized processes are scaled up in our state-of-the-art facilities, utilizing sophisticated bioreactor systems to produce antibodies at a larger scale, ready for purification and downstream processing. Each step in the workflow is documented meticulously, ensuring traceability and adherence to regulatory standards, thus facilitating a smooth transition from development to production.

Our services include:

• Cell clone screening
• Culture media screening and adaptation
• Feeding strategy definition
• Adapting shake flasks to bioreactors
• Critical process parameters identification
• Process characterization
• Process or unit step development and optimization
• Process technology transfer and scale-up

Advantages of Partnering with Creative Biolabs

• Experienced Team: Our team comprises experts with extensive experience in bioprocess engineering and antibody production, ensuring that every project is handled with the highest level of professional expertise.
• State-of-the-Art Technology: Creative Biolabs utilizes state-of-the-art equipment and techniques to develop and optimize upstream processes. Our facilities are equipped with modern bioreactors, high-throughput screening tools, and automated systems, enabling precision and high efficiency in cell culture and antibody production.
• Custom Solutions: Our scientists are committed to developing tailored solutions designed to meet specific client objectives.

Contact Us

Creative Biolabs is dedicated to helping you achieve successful outcomes in antibody production. By choosing our upstream process development service, you gain access to a team of experts committed to excellence, innovation, and client satisfaction. For inquiries and further information about our services, please contact us.

For research use only. Not intended for any clinical use.