APC-HLA-A*01:01/SARS-CoV-2 N (NTNSSPDDQIGYY) MHC Tetramer
CAT#: MHC-YF3617
This product is a MHC tetramer of biotinylated peptide/MHC complex composed N-derived peptide of NTNSSPDDQIGYY sequence covering 75-87 and HLA-A*01:01 molecule. The pMHC tetramer recognizes CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Specifications
- Allele
- HLA-A*01:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- N
- Antigen Species
- SARS-CoV-2
- Peptide
- NTNSSPDDQIGYY
- Range
- 75-87
- Conjugate
- APC
- Application
- FCM
Target
- Antigen Introduction
- Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein. Coronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is a most abundant protein of coronavirus. During virion assembly, N protein binds to viral RNA and leads to formation of the helical nucleocapsid. Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. Because of the conservation of N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.
- Alternative Names
- Nucleocapsid protein, Nucleocapsid, Nucleoprotein, N, NP, Coronavirus NP, Coronavirus Nucleocapsid protein, Coronavirus Nucleocapsid, Coronavirus Nucleoprotein, Coronavirus N, SARS-CoV-2 NP, SARS-CoV-2 Nucleocapsid protein, SARS-CoV-2 Nucleocapsid, SARS-CoV-2 Nucleoprotein, SARS-CoV-2 N
- Gene ID
- 43740575
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Supports Comprehensive T Cell Analysis
By allowing for multicolor flow cytometry, the tetramer enhances our ability to perform in-depth immune profiling. This capability is crucial for understanding the comprehensive immune landscape in COVID-19 research.
Key for Vaccine Development
This tetramer is instrumental in evaluating the effectiveness of COVID-19 vaccines by tracking virus-specific T cell responses. The data it provides is critical for refining vaccine formulations and boosting immune efficacy.
Q&As
-
What is the primary application of the APC-HLA-A01:01/SARS-CoV-2 N 75-87 MHC Tetramer?
A: This MHC tetramer is used in flow cytometry to identify and analyze CD8+ T cells specific to the SARS-CoV-2 nucleocapsid protein. It is particularly valuable in studying immune responses against COVID-19.
-
Why is the SARS-CoV-2 nucleocapsid protein a significant target in COVID-19 research?
A: The nucleocapsid protein plays a crucial role in the virus's structure and replication process. Studying T cell responses to this protein helps in understanding immunity to SARS-CoV-2 and can inform vaccine and therapeutic development strategies.
View the frequently asked questions answered by Creative Biolabs Support.
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