APC-HLA-A*01:01/SARS-CoV-2 N (NTNSSPDDQIGYY) MHC Tetramer (CAT#: MHC-YF3617)

• Allele
• HLA-A*01:01

• Class
• Class I

• MHC Species
• Human

• Antigen
• N

• Antigen Species
• SARS-CoV-2

• Peptide
• NTNSSPDDQIGYY

• Range
• 75-87

• Conjugate
• APC

• Application
• FCM

• Antigen Introduction
• Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein. Coronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is a most abundant protein of coronavirus. During virion assembly, N protein binds to viral RNA and leads to formation of the helical nucleocapsid. Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. Because of the conservation of N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.

• Alternative Names
• Nucleocapsid protein, Nucleocapsid, Nucleoprotein, N, NP, Coronavirus NP, Coronavirus Nucleocapsid protein, Coronavirus Nucleocapsid, Coronavirus Nucleoprotein, Coronavirus N, SARS-CoV-2 NP, SARS-CoV-2 Nucleocapsid protein, SARS-CoV-2 Nucleocapsid, SARS-CoV-2 Nucleoprotein, SARS-CoV-2 N

• Gene ID
• 43740575

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