DRB1*04:01/Human cit fibrinogen-alpha (QDFTN[cit]INKLKNS) MHC Monomer (CAT#: MHC-YF039)
This product is a MHC monomer of biotinylated peptide/MHC complex composed cit fibrinogen-alpha-derived peptide of QDFTN[cit]INKLKNS sequence covering 79-91 and DRB1*04:01 molecule. The pMHC monomer recognizes human CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
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MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.
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Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line Hep G2
(Immunofluorescent staining of human cell line Hep G2 shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/64755/1917_H2_2_selected.jpg
(Immunofluorescent staining of human cell line Hep G2 shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/64755/1917_H2_2_selected.jpg
Figure 2 IHC staining of human small intestine
(Immunohistochemical staining of human small intestine shows distinct positivity in plasma.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51370/ihc_selected.jpg
(Immunohistochemical staining of human small intestine shows distinct positivity in plasma.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51370/ihc_selected.jpg
Figure 3 IHC staining of human nasopharynx
(Immunohistochemical staining of human nasopharynx shows strong cytoplasmic and membranous positivity in respiratory epithelial cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/64755/ihc_selected.jpg
(Immunohistochemical staining of human nasopharynx shows strong cytoplasmic and membranous positivity in respiratory epithelial cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/64755/ihc_selected.jpg
Figure 4 IHC staining of human duodenum
(Immunohistochemical staining of human duodenum shows distinct positivity in plasma.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16776/ihc_selected.jpg
(Immunohistochemical staining of human duodenum shows distinct positivity in plasma.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16776/ihc_selected.jpg
Figure 5 Colon
(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51370/141803_A_9_3.jpg
(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51370/141803_A_9_3.jpg
Figure 6 Kidney
(Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51370/141803_A_8_5.jpg
(Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51370/141803_A_8_5.jpg
Figure 7 RNA cell line category: Cell line enriched (Hep G2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000171560-FGA
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000171560-FGA
Specifications
- Allele
- DRB1*04:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- cit fibrinogen-alpha
- Antigen Species
- Human
- Peptide
- QDFTN[cit]INKLKNS
- Range
- 79-91
- Conjugate
- Biotin
- Application
- MHC Multimer
Target
- Antigen Introduction
- This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing.
- Alternative Names
- Fib2
- Gene ID
- 2243
- UniProt ID
- P02671
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