DRB1*07:01/Human EBNA1 (PGPLRESIVCYFMVFLQTHI) MHC Tetramer
CAT#: MHC-YF888
This product is a MHC tetramer of biotinylated peptide/MHC complex composed EBNA1-derived peptide of PGPLRESIVCYFMVFLQTHI sequence covering 551-570 and DRB1*07:01 molecule. The pMHC tetramer recognizes CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Specifications
- Allele
- DRB1*07:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- EBNA1
- Antigen Species
- EBV
- Peptide
- PGPLRESIVCYFMVFLQTHI
- Range
- 551-570
- Application
- FCM
Target
- Antigen Introduction
- Plays an essential role in replication and partitioning of viral genomic DNA during latent viral infection. During this phase, the circular double-stranded viral DNA undergoes replication once per cell cycle and is efficiently partitioned to the daughter cells. EBNA1 activates the initiation of viral DNA replication through binding to specific sites in the viral latent origin of replication, oriP. Additionally, it governs the segregation of viral episomes by mediating their attachment to host cell metaphase chromosomes. Also activates the transcription of several viral latency genes. Finally, it can counteract the stabilization of host p53/TP53 by host USP7, thereby decreasing apoptosis and increasing host cell survival.
- Alternative Names
- EBNA-1; EBV EBNA1; EBNA1
- Gene ID
- 3783709
- UniProt ID
- P03211
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