DRB1*15:01/Mycobacterium tuberculosis Mtb PE family protein (MHVSFVMAYPEMLAA) MHC Monomer
CAT#: MHC-YF124
This product is a MHC monomer of biotinylated peptide/MHC complex composed Mtb PE family protein-derived peptide of MHVSFVMAYPEMLAA sequence and DRB1*15:01 molecule. The pMHC monomer recognizes human CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Specifications
- Allele
- DRB1*15:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- Mtb PE family protein
- Antigen Species
- Mycobacterium tuberculosis
- Peptide
- MHVSFVMAYPEMLAA
- Conjugate
- Biotin
- Application
- MHC Multimer
Target
- Antigen Introduction
- Induces TNF-alpha release through human Toll-like receptor 2 (TLR2) signaling pathway, leading to macrophage apoptosis (PubMed:17095513, PubMed:17223373, PubMed:24106104). The signaling pathway involves TLR2-dependent activation of the mitogen-activated protein kinase kinase kinase 5 (ASK1), which activates the p38 and JNK MAPKs, leading to enhanced expression of TNF-alpha and tumor necrosis factor receptor superfamily member 1A (TNFRI) genes. Signals are amplified through classical caspase 8-dependent mitochondrial release of cytochrome c, leading to the activation of caspases 9 and 3 . Mediates Ca2+-dependent up-regulation of the anti-inflammatory cytokine IL-10. Mediates entry into macrophages in a TLR2-dependent mechanism and activates the TLR2-dependent pro-adhesive pathway.
- Alternative Names
- PE-PGRS family protein PE_PGRS33; PE_PGRS33; PE
- Gene ID
- 885551
- UniProt ID
- P9WIF5
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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