Recombinant Human Anti-EBV BZLF1 Soluble TCR (SB47) (KIH)
CAT#: VS-0622-YF5431
Human TCR (SB47) recognizes EBV BZLF1 peptide (LPEPLPQGQLTAY) in the context of HLA-B*3505. Soluble TCR is expressed with Knob-in-hole (KIH) strategy (scTCR-hIgG Knob, scTCR-hIgG Hole). Please note that the activity is not guaranteed.
Specifications
- Host Species
- Human
- Target
- EBV BZLF1
- Species Reactivity
- EBV
- Epitope
- LPEPLPQGQLTAY
- MHC
- HLA-B*3505
- Clone
- SB47
- Type
- Soluble TCR (KIH)
- Related Disease
- EBV infection
- TCR Expression Strategy
- KIH strategy: scTCR-human IgG Knob and scTCR-human IgG Hole can form heterodimer based on Knob-in-hole (KIH) strategy. The soluble TCR contains single chain TCR. With this KIH antibody production strategy, VL/VH will be replaced with Valpha-linker-Vbeta (single chain TCR).
Target
- Alternative Names
- BZLF1; Trans-activator protein BZLF1
- UniProt ID
- Q3KSS8
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Advanced KIH Production
The Knob-in-hole strategy used for the SB47 clone is very impressive. It allowed us to study the switch from latent infection to the lytic cycle in EBV by targeting the BZLF1 peptide presented by HLA-B*3505.
Key For Transcription Factor Study
We used this soluble TCR to investigate the role of BZLF1 as a transcription factor. The product effectively recognized the target peptide LPEPLPQGQLTAY, which helped us understand its function in inducing early lytic cycle genes.
Q&As
-
What is the function of the EBV BZLF1 protein?
A: BZLF1 plays a key role in the switch from latent infection to the lytic cycle, producing new virions. It acts as a transcription factor inducing early lytic genes and as an origin binding protein for genome replication.
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How is the soluble TCR SB47 constructed?
A: The soluble TCR SB47 is expressed using the Knob-in-hole (KIH) strategy, where scTCR-human IgG Knob and scTCR-human IgG Hole form a heterodimer. The VL/VH regions are replaced with the Valpha-linker-Vbeta single chain TCR.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone SB47"
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- Product Name
See other products for "EBV BZLF1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC412 | PE-B*08:01/EBV BZLF1 (RAKFKQLL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC413 | APC-B*08:01/EBV BZLF1 (RAKFKQLL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1277 | PE-B*35:01/EBV BZLF1 (LPEPLPQGQLTAY) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1316 | PE-B*35:08/EBV BZLF1 (APQPAPENAY) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1319 | PE-B*35:01/EBV BZLF1 (APQPAPENAY) MHC Tetramer | FCM |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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