Recombinant Human Anti-α-GlcCer Soluble TCR (9B2) (KIH)
CAT#: VS-0622-YF8122
Human TCR (9B2) recognizes α-GlcCer peptide (α-Glucosylceramide) in the context of human CD1d. Soluble TCR is expressed with Knob-in-hole (KIH) strategy (scTCR-hIgG Knob, scTCR-hIgG Hole). Please note that the activity is not guaranteed.
Specifications
- Host Species
- Human
- Target
- α-GlcCer
- Epitope
- α-Glucosylceramide
- MHC
- human CD1d
- Clone
- 9B2
- Type
- Soluble TCR (KIH)
- TCR Expression Strategy
- KIH strategy: scTCR-human IgG Knob and scTCR-human IgG Hole can form heterodimer based on Knob-in-hole (KIH) strategy. The soluble TCR contains single chain TCR. With this KIH antibody production strategy, VL/VH will be replaced with Valpha-linker-Vbeta (single chain TCR).
Target
- Alternative Names
- alpha-Glucosylceramide
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Innovative KIH Strategy
We were interested in the Knob-in-hole strategy used for this soluble TCR. It effectively formed the heterodimer we needed to study the recognition of alpha-Glucosylceramide in the context of human CD1d. A very sophisticated tool.
Useful For Lipid Studies
This product helped us explore sugar sphingolipids found in various organisms. The 9B2 clone showed interaction with the target peptide, and the documentation provided regarding the single-chain variable regions was quite helpful for our assay design.
Q&As
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What strategy is used to express this soluble TCR?
A: This soluble TCR is expressed using the Knob-in-hole (KIH) strategy. This involves the formation of a heterodimer using scTCR-human IgG Knob and scTCR-human IgG Hole, where VL/VH regions are replaced with the single-chain TCR.
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What organisms naturally contain Glucosylceramide?
A: Glucosylceramide (GlcCer) is found in plants, fungi, and animals. Notably, it is absent in bacteria and in some eukaryotes such as the baker yeast Saccharomyces cerevisiae. Our TCR targets the alpha-GlcCer peptide in the context of human CD1d.
View the frequently asked questions answered by Creative Biolabs Support.
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