Recombinant Anti-ADAM15 Vesicular Antibody, EV Displayed (VS-0425-YC361)
CAT#: VS-0425-YC361
The Recombinant Anti-ADAM15 Vesicular Antibody, EV Displayed (VS-0425-YC361) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ADAM15-expressed cells or tissues. The ADAM15 is an ADAM protein involved in adhesion and signaling, interacting with integrins and Src family kinases.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line SiHa
Immunofluorescent staining of human cell line SiHa shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/72878/1611_E7_2_selected.jpg
Normal Tissue
Figure 2 IHC staining of human skin
Immunohistochemical staining of human skin shows cytoplasmic positivity in basal cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11633/30632_B_7_1_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11633/30632_B_7_5.jpg
Normal Tissue
Figure 4 Colon
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11633/30632_A_8_3.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11633/30632_A_9_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11633/30632_A_8_5.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11633/30632_A_6_6.jpg
Normal Tissue
Figure 8 Lymph node
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11633/30632_A_9_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (PC-3, RPMI-8226)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000143537-ADAM15
❮
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ADAM15
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- ADAM metallopeptidase domain 15
- Biological Process
- Angiogenesis, Cell adhesion, Collagen degradation
- Molecular Function
- Hydrolase, Metalloprotease, Protease
- Cellular Localization
- Vesicles
- Introduction
- The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.
- Alternative Names
- MDC15
- Gene ID
- 8751
- UniProt ID
- Q13444
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Datasheet
MSDS
COA
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|---|---|---|---|
| MOB-37 | Recombinant Anti-human ADAM15 Antibody | ELISA, WB, IF, FuncS | IgG |
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| MOB-0436MZ | Mouse Anti-ADAM15 Recombinant Antibody (clone NN0089-0I45) | WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
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| MOB-37-F(E) | Recombinant Anti-human ADAM15 Antibody Fab Fragment | WB, FACS, FuncS | Fab |
| MHH-37-F(E) | Recombinant Human Anti-human ADAM15 Antibody Fab Fragment | ELISA, IP, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-37-S(P) | Recombinant Anti-human ADAM15 Antibody scFv Fragment | ELISA, WB, FuncS | scFv |
| MHH-37-S(P) | Recombinant Human Anti-human ADAM15 Antibody scFv Fragment | FC, RIA, Biosensors, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-313CT-S(P) | Mouse Anti-ADAM15 Recombinant Antibody; scFv Fragment (TAB-313CT-S(P)) | ELISA | Mouse scFv |
| TAB-313CT-F(E) | Mouse Anti-ADAM15 Recombinant Antibody; Fab Fragment (TAB-313CT-F(E)) | ELISA | Mouse Fab |
| TAB-314CT-F(E) | Mouse Anti-ADAM15 Recombinant Antibody; Fab Fragment (TAB-314CT-F(E)) | ELISA | Mouse Fab |
| TAB-0666CLV-F(E) | Mouse Anti-ADAM15 Recombinant Antibody; Fab Fragment (TAB-0666CLV-F(E)) | ELISA | Mouse Fab |
| TAB-0666CLV-S(P) | Mouse Anti-ADAM15 Recombinant Antibody; scFv Fragment (TAB-0666CLV-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0069 | Hi-Affi™ Rabbit Anti-ADAM15 Recombinant Antibody (clone DS69AB) | WB, IHC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY147 | Anti-ADAM15 Immunohistochemistry Kit | IHC | |
| VS-0525-XY148 | Anti-Mouse ADAM15 Immunohistochemistry Kit | IHC |
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