Recombinant Anti-ART4 Vesicular Antibody, EV Displayed (VS-0425-YC737) (CAT#: VS-0425-YC737)

• Application
• ELISA, FC, Cell-uptake

• Product Type
• Ab-Fc-EVs

• Antibody Quantification (Ab/EV)
• ~100 Ab/EV

• Target
• ART4

• Host Animal
• Human

• Antibody Isotype
• IgG

• Species Reactivity
• Human

• Expression Cell
• Mammalian cell

• EV-sorting domain
• CD63

• Fc-binding domain
• z domain

• EV Size
• 30~150 nm

• Producing Cell
• HEK293F

• Isolation Method
• Gradient centrifugation

• Purification
• qEV size exclusion chromatography

• Binding Affinity
• Kd = 0.85 µg/mL

• Concentration
• 1 x 10¹⁰

• Size
• 1 mL

• Buffer
• PBS

• Storage
• Store at -80°C for 12 months

• Full Name
• ADP-ribosyltransferase 4 (inactive) (Dombrock blood group)

• Molecular Function
• Blood group antigen, Glycosyltransferase, Nucleotidyltransferase, Transferase

• Cellular Localization
• Rods & Rings

• Introduction
• This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known.

• Alternative Names
• ARTC4, CD297, DO, DOK1

• Gene ID
• 420

• UniProt ID
• Q93070

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