Recombinant Anti-CLEC2D Vesicular Antibody, EV Displayed (VS-0425-YC310) (CAT#: VS-0425-YC310)
The Recombinant Anti-CLEC2D Vesicular Antibody, EV Displayed (VS-0425-YC310) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to CLEC2D-expressed cells or tissues. The CLEC2D is a C-type lectin family protein inhibiting osteoclast formation, featuring transmembrane and extracellular domains with variant isoforms.
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/47584/747_H3_2_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/47584/747_H3_2_selected.jpg
Figure 2 IHC staining of human colon
(Immunohistochemical staining of human colon shows strong positivity in glandular cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17649/ihc_selected.jpg
(Immunohistochemical staining of human colon shows strong positivity in glandular cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17649/ihc_selected.jpg
Figure 3 IF staining of human cell line MCF7
(Immunofluorescent staining of human cell line MCF7 shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/47584/714_H3_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line MCF7 shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/47584/714_H3_1_blue_red_green.jpg
Figure 4 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/47584/713_H3_2_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/47584/713_H3_2_blue_red_green.jpg
Figure 5 Colon
(Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Peripheral nerve/ganglion
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17649/40429_A_9_3.jpg
(Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Peripheral nerve/ganglion
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17649/40429_A_9_3.jpg
Figure 6 Kidney
(Cells in glomeruli
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17649/40429_A_8_5.jpg
(Cells in glomeruli
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17649/40429_A_8_5.jpg
Figure 7 Testis
(Cells in seminiferous ducts
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17649/40429_A_4_6.jpg
(Cells in seminiferous ducts
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17649/40429_A_4_6.jpg
Figure 8 Lymph node
(Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17649/40429_A_7_8.jpg
(Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17649/40429_A_7_8.jpg
Figure 9 RNA cell line category: Group enriched (Daudi, HDLM-2, Karpas-707, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000069493-CLEC2D
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000069493-CLEC2D
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- CLEC2D
- Host Animal
- Mouse
- Antibody Isotype
- IgG1
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein G
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- C-type lectin domain family 2 member D
- Molecular Function
- Receptor
- Cellular Localization
- Golgi apparatus
- Introduction
- This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Oct 2010]
- Alternative Names
- CLAX, LLT1, OCIL
- Gene ID
- 29121
- UniProt ID
- Q9UHP7
Downloads
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Mouse Antibody Products
IgG Antibody Products
Rabbit Monoclonal Antibody Products
ScFv Antibody Products
Fab Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0684CL | Mouse Anti-CLEC2D Recombinant Antibody (TAB-0684CL) | FC, ELISA | Mouse IgG1 |
| TAB-0685CL | Mouse Anti-CLEC2D Recombinant Antibody (TAB-0685CL) | FC, ELISA | Mouse IgG1 |
| TAB-0684CL-S(P) | Mouse Anti-CLEC2D Recombinant Antibody; scFv Fragment (TAB-0684CL-S(P)) | FC, ELISA | Mouse scFv |
| TAB-0684CL-F(E) | Mouse Anti-CLEC2D Recombinant Antibody; Fab Fragment (TAB-0684CL-F(E)) | FC, ELISA | Mouse Fab |
| TAB-0685CL-F(E) | Mouse Anti-CLEC2D Recombinant Antibody; Fab Fragment (TAB-0685CL-F(E)) | FC, ELISA | Mouse Fab |
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