Recombinant Anti-CLEC4M Vesicular Antibody, EV Displayed (VS-0425-YC725)
CAT#: VS-0425-YC725
The Recombinant Anti-CLEC4M Vesicular Antibody, EV Displayed (VS-0425-YC725) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to CLEC4M-expressed cells or tissues. CLEC4M is a transmembrane receptor known as L-SIGN, expressed in lymph node and liver endothelial cells. It's involved in pathogen recognition and cell adhesion, with domains for carbohydrate binding and homo-oligomerization affecting ligand affinity.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human liver
Immunohistochemical staining of human liver shows distinct positivity in liver sinusoids.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42661/ihc_selected.jpg
Normal Tissue
Figure 2 IHC staining of human liver
Immunohistochemical staining of human liver shows distinct positivity in sinusoidal endothelial cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/33689/ihc_selected.jpg
Normal Tissue
Figure 3 IHC staining of human liver
Immunohistochemical staining of human liver shows distinct staining in sinusoidal endothelial cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/33691/ihc_selected.jpg
Normal Tissue
Figure 4 Testis
Leydig cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/33689/80799_A_6_6.jpg
RNA Expression
Figure 1 RNA cell line category: Not detected
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000104938-CLEC4M
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- CLEC4M
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- C-type lectin domain family 4 member M
- Biological Process
- Adaptive immunity, Endocytosis, Host-virus interaction, Immunity, Innate immunity
- Molecular Function
- Host cell receptor for virus entry, Receptor
- Introduction
- This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]
- Alternative Names
- CD209L, CD299, DC-SIGN2, DC-SIGNR, DCSIGNR, HP10347, LSIGN
- Gene ID
- 10332
- UniProt ID
- Q9H2X3
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Datasheet
MSDS
COA
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See other products for "CLEC4M"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2352z | Mouse Anti-CLEC4M Recombinant Antibody (clone 41A10) | WB, FC, IHC, FuncS | Mouse IgG1 |
| MOB-2353MZ | Recombinant Mouse Anti-Human CLEC4M Antibody (clone NN0352- 3V36) | FC, Neut | Mouse antibody |
| FAMAB-1108CQ | Mouse Anti-CLEC4M Recombinant Antibody (clone 16E7) | FC, IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-312CQ | Mouse Anti-CLEC4M Recombinant Antibody (clone CBL321) | CyTOF®, FC, Block | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-471CQ | Mouse Anti-CLEC4M Recombinant Antibody (clone CBL018) | Neut, FC | Mouse IgG2 |
| NEUT-472CQ | Mouse Anti-CLEC4M Recombinant Antibody (clone MM0241-2U25) | Neut, FC | Mouse IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0724 | Hi-Affi™ Rabbit Anti-CLEC4M Recombinant Antibody (clone DS724AB) | WB, IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1502 | Anti-CLEC4M Immunohistochemistry Kit | IHC |
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