Recombinant Anti-CMKLR1 Vesicular Antibody, EV Displayed (VS-0425-YC684) (CAT#: VS-0425-YC684)
The Recombinant Anti-CMKLR1 Vesicular Antibody, EV Displayed (VS-0425-YC684) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to CMKLR1-expressed cells or tissues. CMKLR1 enables hormone and chemokine-like receptor activities, involved in thermogenesis and adipocyte differentiation, having orthologous human proteins.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 IHC staining of human kidney
(Immunohistochemical staining of human kidney shows moderate cytoplasmic positivity in renal tubules.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47865/ihc_selected.jpg
(Immunohistochemical staining of human kidney shows moderate cytoplasmic positivity in renal tubules.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47865/ihc_selected.jpg
Figure 2 Parathyroid gland
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47865/109996_A_3_8.jpg
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47865/109996_A_3_8.jpg
Figure 3 Liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47865/109996_A_8_4.jpg
(Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47865/109996_A_8_4.jpg
Figure 4 Kidney
(Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47865/109996_A_9_5.jpg
(Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47865/109996_A_9_5.jpg
Figure 5 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47865/109996_A_4_6.jpg
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47865/109996_A_4_6.jpg
Figure 6 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, BJ hTERT+, hTERT-RPE1, LHCN-M2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000174600-CMKLR1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000174600-CMKLR1
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- CMKLR1
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Chemerin chemokine-like receptor 1
- Molecular Function
- G-protein coupled receptor, Receptor, Transducer
- Introduction
- Predicted to enable adipokinetic hormone binding activity; adipokinetic hormone receptor activity; and transmembrane signaling receptor activity. Involved in negative regulation of interleukin-12 production; positive regulation of cold-induced thermogenesis; and positive regulation of fat cell differentiation. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; embryo mesenchyme; jaw; lung; and uterus. Orthologous to human CMKLR1 (chemerin chemokine-like receptor 1).
- Alternative Names
- ChemR23, DEZ, Gpcr27, mcmklr1
- Gene ID
- 14747
- UniProt ID
- P97468
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Neutralizing Antibody Products
IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-481CQ | Rat Anti-CMKLR1 Recombinant Antibody (clone CBL372) | Neut, WB | Rat IgG2a |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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