Recombinant Anti-CXADR Vesicular Antibody, EV Displayed (VS-0425-YC283) (CAT#: VS-0425-YC283)
The Recombinant Anti-CXADR Vesicular Antibody, EV Displayed (VS-0425-YC283) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to CXADR-expressed cells or tissues. The CXADR is a cell adhesion molecule involved in pathways like immune response and is linked to diseases such as myocarditis and cardiomyopathy.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm, plasma membrane & cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30411/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm, plasma membrane & cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30411/if_selected.jpg
Figure 2 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5103/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5103/if_selected.jpg
Figure 3 IHC staining of human salivary gland
(Immunohistochemical staining of human salivary gland shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3342/ihc_selected.jpg
(Immunohistochemical staining of human salivary gland shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3342/ihc_selected.jpg
Figure 4 Rectum
(High expression in rectum)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30411/63345_A_5_3_val_selected.jpg
(High expression in rectum)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30411/63345_A_5_3_val_selected.jpg
Figure 5 Liver
(Cholangiocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30411/63345_A_7_4.jpg
(Cholangiocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30411/63345_A_7_4.jpg
Figure 6 Testis
(Sertoli cells Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30411/63345_A_6_6.jpg
(Sertoli cells Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30411/63345_A_6_6.jpg
Figure 7 Skin
(Cells in basal layer Staining: Medium Intensity: Moderate Quantity:>75% Cells in spinous layer Staining: Medium Intensity: Moderate Quantity: 75%-25% Eccrine glands Staining: Medium Intensity: Moderate Quantity: 75%-25% Endothelial cells Staining: Medium Intensity: Moderate Fibrohistiocytic cells Staining: High Intensity: Strong Hair follicles Staining: Medium Intensity: Moderate Quantity:>75% Langerhans cells Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30411/63345_B_8_1.jpg
(Cells in basal layer Staining: Medium Intensity: Moderate Quantity:>75% Cells in spinous layer Staining: Medium Intensity: Moderate Quantity: 75%-25% Eccrine glands Staining: Medium Intensity: Moderate Quantity: 75%-25% Endothelial cells Staining: Medium Intensity: Moderate Fibrohistiocytic cells Staining: High Intensity: Strong Hair follicles Staining: Medium Intensity: Moderate Quantity:>75% Langerhans cells Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30411/63345_B_8_1.jpg
Figure 8 RNA cell line category: Cell line enhanced (CACO-2, Hep G2, NTERA-2, RT4)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000154639-CXADR
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000154639-CXADR
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- CXADR
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- CXADR Ig-like cell adhesion molecule
- Biological Process
- Cell adhesion, Host-virus interaction
- Molecular Function
- Host cell receptor for virus entry, Receptor
- Cellular Localization
- Plasma membrane, Cell Junctions, Nucleoplasm
- Introduction
- CXADR (CXADR, Ig-Like Cell Adhesion Molecule) is a Protein Coding gene. Diseases associated with CXADR include Myocarditis and Dilated Cardiomyopathy. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. Gene Ontology (GO) annotations related to this gene include identical protein binding and integrin binding. An important paralog of this gene is ENSG00000277666.
- Alternative Names
- CAR
- Gene ID
- 1525
- UniProt ID
- P78310
Downloads
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2024z | Mouse Anti-CXADR Recombinant Antibody (clone 33A2) | WB, ICC, IF, IHC | Mouse IgG1 |
| MOB-0719MZ | Recombinant Mouse Anti-Human CXADR Antibody (clone 3U7) | ICC | Mouse antibody |
| VS-0723-WK60 | Human Anti-CXADR Recombinant Antibody (VS-0723-WK60) | FC | Chimeric (rabbit/human) IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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