Recombinant Anti-FCAR Vesicular Antibody, EV Displayed (VS-0425-YC346)
CAT#: VS-0425-YC346
The Recombinant Anti-FCAR Vesicular Antibody, EV Displayed (VS-0425-YC346) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to FCAR-expressed cells or tissues. The FCAR is an IgA receptor mediating immunologic responses, with roles in phagocytosis and cell-mediated cytotoxicity.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14050/if_selected.jpg
Subcellular Location
Figure 2 IHC staining of human lymph node
Immunohistochemical staining of human lymph node shows moderate cytoplasmic positivity in reaction center cells and lymphoid cells outside reaction centra.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14050/ihc_selected.jpg
Normal Tissue
Figure 3 Bone marrow
Hematopoietic cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14050/32713_B_4_4.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14050/32713_A_9_8.jpg
RNA Expression
Figure 5 RNA cell line category: Not detected
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000186431-FCAR
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Recombinant Antibody
- Application
- ELISA, FC, Inhib, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- FCAR
- Host Animal
- Human
- Antibody Isotype
- IgG1 kappa
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Fc alpha receptor
- Molecular Function
- IgA-binding protein, Receptor
- Cellular Localization
- Plasma membrane
- Introduction
- This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
- Alternative Names
- CD89, FcalphaR, FcalphaRI
- Gene ID
- 2204
- UniProt ID
- P24071
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Datasheet
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COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1200z | Mouse Anti-FCAR Recombinant Antibody (clone 44C11) | WB, ELISA, FC, IP | Mouse IgG1 |
| MOB-0522CT | Recombinant Mouse anti-Human FCAR Monoclonal antibody (NJQ8d) | FC, Inhib | |
| HPAB-1202WJ | Human Anti-FCAR Recombinant Antibody (clone 14A8) | ELISA, FC | Human IgG |
| HPAB-1203WJ | Human Anti-FCAR Recombinant Antibody (clone 8D2) | ELISA, FC | Human IgG |
| HPAB-2118-FY | Mouse Anti-FCAR Recombinant Antibody (clone A77) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-031WM | Anti-Human FCAR Recombinant Antibody (7F12) | ELISA, FC, BL, Inhib, IP | Human Antibody |
| TAB-031WM-S(P) | Anti-Human FCAR Recombinant Antibody scFv Fragment (7F12) | ELISA, FC, BL, Inhib, IP | Human Antibody |
| TAB-031WM-F(E) | Anti-Human FCAR Recombinant Antibody Fab Fragment (7F12) | ELISA, FC, BL, Inhib, IP | Human Antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-783CQ | Mouse Anti-FCAR Recombinant Antibody (clone MIP7c) | FC, Inhib | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1267 | Hi-Affi™ Rabbit Anti-FCAR Recombinant Antibody (clone DS1267AB) | WB, IHC, ICC, IP, FC | Rabbit IgG |
| MOR-4073 | Hi-Affi™ Rabbit Anti-Fcar Recombinant Antibody (clone SI140DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1202WJ-S(P) | Human Anti-FCAR Recombinant Antibody (clone 14A8); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-1203WJ-S(P) | Human Anti-FCAR Recombinant Antibody (clone 8D2); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-2118-FY-S(P) | Mouse Anti-FCAR Recombinant Antibody (clone A77); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1202WJ-F(E) | Human Anti-FCAR Recombinant Antibody (clone 14A8); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-1203WJ-F(E) | Human Anti-FCAR Recombinant Antibody (clone 8D2); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-2118-FY-F(E) | Mouse Anti-FCAR Recombinant Antibody (clone A77); Fab Fragment | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY99 | AbPlus™ Anti-FCAR Magnetic Beads (7F12) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY113 | Mouse Anti-NHP FCAR Recombinant Antibody (clone A59) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2474 | Anti-FCAR Immunohistochemistry Kit | IHC |
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