Recombinant Anti-GABRA5 Vesicular Antibody, EV Displayed (VS-0425-YC394)
CAT#: VS-0425-YC394
The Recombinant Anti-GABRA5 Vesicular Antibody, EV Displayed (VS-0425-YC394) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to GABRA5-expressed cells or tissues. The GABRA5 is a subunit of the GABA-A receptor involved in inhibitory neurotransmission, with its chlorinated conductance modulated by agents binding to the GABA-A receptor.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to nucleoplasm, plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77031/1636_C3_12_cr594b6bc332658_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (A549, HAP1, NTERA-2, U-2 OS)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000186297-GABRA5
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- GABRA5
- Host Animal
- Human
- Antibody Isotype
- IgG1
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Gamma-aminobutyric acid type A receptor subunit alpha5
- Biological Process
- Ion transport, Transport
- Molecular Function
- Chloride channel, Ion channel, Ligand-gated ion channel, Receptor
- Cellular Localization
- Plasma membrane, Nucleoplasm, Actin filaments, Cytosol
- Introduction
- GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described.
- Gene ID
- 2558
- UniProt ID
- P31644
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Datasheet
MSDS
COA
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