Recombinant Anti-GABRA5 Vesicular Antibody, EV Displayed (VS-0425-YC394)
CAT#: VS-0425-YC394
The Recombinant Anti-GABRA5 Vesicular Antibody, EV Displayed (VS-0425-YC394) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to GABRA5-expressed cells or tissues. The GABRA5 is a subunit of the GABA-A receptor involved in inhibitory neurotransmission, with its chlorinated conductance modulated by agents binding to the GABA-A receptor.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to nucleoplasm, plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77031/1636_C3_12_cr594b6bc332658_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (A549, HAP1, NTERA-2, U-2 OS)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000186297-GABRA5
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- GABRA5
- Host Animal
- Human
- Antibody Isotype
- IgG1
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Gamma-aminobutyric acid type A receptor subunit alpha5
- Biological Process
- Ion transport, Transport
- Molecular Function
- Chloride channel, Ion channel, Ligand-gated ion channel, Receptor
- Cellular Localization
- Plasma membrane, Nucleoplasm, Actin filaments, Cytosol
- Introduction
- GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described.
- Gene ID
- 2558
- UniProt ID
- P31644
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Datasheet
MSDS
COA
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See other products for "GABRA5"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1385 | Hi-Affi™ Rabbit Anti-GABRA5 Recombinant Antibody (clone DS1385AB) | WB, ICC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0616-CN | Rabbit Anti-GABRA5 Recombinant Antibody (clone JB34-19) | WB, IF, IHC | Rabbit IgG |
| VS-0422-LC81 | Rat Anti-GABRA5 Recombinant Antibody (clone rtN415/24R) | WB | Rat IgG2b |
| VS-0422-LC82 | Human Anti-GABRA5 Recombinant Antibody (clone hN415/24R) | WB | Human IgG1 |
| VS-0522-LC91 | Mouse Anti-GABRA5 Recombinant Antibody (VS-0522-LC91) | WB | Mouse IgG1 |
| VS-0522-LC92 | Rat Anti-GABRA5 Recombinant Antibody (VS-0522-LC92) | WB | Rat IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2706 | Anti-GABRA5 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2707 | Anti-Mouse GABRA5 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2708 | Anti-Rat GABRA5 Immunohistochemistry Kit | IHC |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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