Recombinant Anti-GRIA2 Vesicular Antibody, EV Displayed (VS-0425-YC65)

CAT#: VS-0425-YC65

The Recombinant Anti-GRIA2 Vesicular Antibody, EV Displayed (VS-0425-YC65) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to GRIA2-expressed cells or tissues. The GRIA2 is a subunit of glutamate receptors, critical in neurophysiological processes sensitive to AMPA.

Gene Expression
Figure 1 Cerebral cortex Figure 2 Hippocampus Figure 3 RNA cell line category: Cell line enriched (SCLC-21H)

Recombinant Antibody

  • Application
  • ELISA, FC, Cell-uptake
  • Product Type
  • Ab-Fc-EVs
  • Antibody Quantification (Ab/EV)
  • ~100 Ab/EV
  • Target
  • GRIA2
  • Host Animal
  • Rabbit
  • Antibody Isotype
  • IgG
  • Species Reactivity
  • Rat, Mouse
  • Expression Cell
  • Mammalian cell

Engineered EVs

  • EV-sorting domain
  • CD63
  • Fc-binding domain
  • Protein A
  • EV Size
  • 30~150 nm
  • Producing Cell
  • HEK293F
  • Isolation Method
  • Gradient centrifugation
  • Purification
  • qEV size exclusion chromatography
  • Concentration
  • 1 x 10¹⁰
  • Size
  • 1 mL
  • Buffer
  • PBS
  • Storage
  • Store at -80°C for 12 months

Target

  • Full Name
  • Glutamate ionotropic receptor AMPA type subunit 2
  • Biological Process
  • Ion transport, Transport
  • Molecular Function
  • Ion channel, Ligand-gated ion channel, Receptor
  • Introduction
  • Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+).
  • Alternative Names
  • GluA2, GluR-B, Glur-2, Glur2, gluR-K2
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