Recombinant Anti-HCRTR1 Vesicular Antibody, EV Displayed (VS-0425-YC544) (CAT#: VS-0425-YC544)
The Recombinant Anti-HCRTR1 Vesicular Antibody, EV Displayed (VS-0425-YC544) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to HCRTR1-expressed cells or tissues. HCRTR1 is a receptor involved in feeding behavior regulation by binding orexin A. HCRTR1 is related to another receptor, HCRTR2, which binds both orexin A and B.
Specific Inquiry
Normal Tissue
Figure 1 Cerebral cortex
(Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14018/166801_B_9_5.jpg
(Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14018/166801_B_9_5.jpg
Figure 2 Colon
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14018/166801_A_7_3.jpg
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14018/166801_A_7_3.jpg
Figure 3 Kidney
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14018/166801_A_7_5.jpg
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14018/166801_A_7_5.jpg
Figure 4 Testis
(Elongated or late spermatids Staining: High Intensity: Strong Quantity:>75% Leydig cells Staining: Low Intensity: Weak Quantity:>75% Round or early spermatids Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14018/166801_A_6_6.jpg
(Elongated or late spermatids Staining: High Intensity: Strong Quantity:>75% Leydig cells Staining: Low Intensity: Weak Quantity:>75% Round or early spermatids Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14018/166801_A_6_6.jpg
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- HCRTR1
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Hypocretin receptor 1
- Molecular Function
- G-protein coupled receptor, Receptor, Transducer
- Introduction
- The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B.
- Alternative Names
- ORXR1, OX1R, OXR1
- Gene ID
- 3061
- UniProt ID
- O43613
Downloads
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Neuroscience Antibody Products
ScFv Antibody Products
IgG Antibody Products
Fab Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-066CN | Mouse Anti-HCRTR1 Recombinant Antibody (clone 5E12) | ELISA | Mouse IgG2a |
| NS-066CN-F(E) | Mouse Anti-HCRTR1 Recombinant Antibody (clone 5E12); Fab Fragment | ELISA | Mouse Fab |
| NS-066CN-S(P) | Mouse Anti-HCRTR1 Recombinant Antibody (clone 5E12); scFv Fragment | ELISA | Mouse scFv |
| NS-065CN | Human Anti-HCRTR1 Recombinant Antibody (NS-065CN) | ELISA | Human IgG |
| NS-065CN-F(E) | Human Anti-HCRTR1 Recombinant Antibody; Fab Fragment (NS-065CN-F(E)) | ELISA | Human Fab |
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