Recombinant Anti-IL6ST Vesicular Antibody, EV Displayed (VS-0425-YC568)
CAT#: VS-0425-YC568
The Recombinant Anti-IL6ST Vesicular Antibody, EV Displayed (VS-0425-YC568) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to IL6ST-expressed cells or tissues. IL6ST is a cytokine receptor signal transducer, impacting cell signaling and apoptosis regulation.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25784/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human placenta
Immunohistochemical staining of human placenta shows cytoplasmic positivity in trophoblastic cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10558/26501_A_2_7_selected.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10558/26501_A_9_3.jpg
Normal Tissue
Figure 4 Testis
Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10558/26501_A_5_6.jpg
Normal Tissue
Figure 5 Lymph node
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10558/26501_A_9_8.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (ASC TERT1, BJ hTERT+, HHSteC, HSkMC, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134352-IL6ST
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- IL6ST
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Interleukin 6 cytokine family signal transducer
- Biological Process
- Host-virus interaction
- Molecular Function
- Receptor
- Cellular Localization
- Plasma membrane, Golgi apparatus
- Introduction
- The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]
- Alternative Names
- CD130, GP130, IL-6RB, sGP130
- Gene ID
- 3572
- UniProt ID
- P40189
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Datasheet
MSDS
COA
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| NEUT-1497CQ | Mouse Anti-IL6ST Recombinant Antibody (clone 9X23) | FC, Neut | Mouse IgG1 |
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| NEUT-1498CQ | Mouse Anti-IL6ST Recombinant Antibody (clone CBL445) | ELISA, Neut | Mouse IgG1 |
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| NEUT-1499CQ | Mouse Anti-IL6ST Recombinant Antibody (clone CBL446) | FC, CyTOF, Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
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| NEUT-1500CQ | Mouse Anti-IL6ST Recombinant Antibody (clone B-P4) | ELISA, Inhib | Mouse IgG1 |
| CAT | Product Name | Application | Type |
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| NEUT-1501CQ | Rat Anti-Il6st Recombinant Antibody (clone CBL287) | ELISA, Neut | Rat IgG1 |
| CAT | Product Name | Application | Type |
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| NEUT-1502CQ | Rat Anti-Il6st Recombinant Antibody (clone CBL533) | ELISA, Neut | Rat IgG1 |
| CAT | Product Name | Application | Type |
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| MOR-4279 | Rabbit Anti-Il6st Recombinant Antibody (clone SI362DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
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| MOR-4280 | Rabbit Anti-IL6ST Recombinant Antibody (clone SI363DS) | FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
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| HPAB-0406-YC | Mouse Anti-IL6ST Recombinant Antibody (HPAB-0406-YC) | ELISA, FC, WB, FuncS | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0406-YC-S(P) | Mouse Anti-IL6ST Recombinant Antibody; scFv Fragment (HPAB-0406-YC-S(P)) | ELISA, FC, WB, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0406-YC-F(E) | Mouse Anti-IL6ST Recombinant Antibody; Fab Fragment (HPAB-0406-YC-F(E)) | ELISA, FC, WB, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0274-CN | Mouse Anti-IL6ST Recombinant Antibody (clone B11-B9-A8) | WB, IHC, IF | Mouse IgG2b |
| CAT | Product Name | Application | Type |
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| VS-0325-XY1121 | Anti-IL6ST Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| VS-1025-YC124 | Anti-IL6ST Antibody Prodrug, Protease Activated (VS-1025-YC124) | ISZ, Cyt, FuncS |
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