Recombinant Anti-ITGB4 Vesicular Antibody, EV Displayed (VS-0425-YC521)
CAT#: VS-0425-YC521
The Recombinant Anti-ITGB4 Vesicular Antibody, EV Displayed (VS-0425-YC521) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ITGB4-expressed cells or tissues. ITGB4 is an integrin beta 4 subunit, forming complexes with various alpha subunits to mediate cell adhesion. This subunit is pivotal in invasive carcinoma biology and is associated with epidermolysis bullosa with pyloric atresia.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HaCaT
Immunofluorescent staining of human cell line HaCaT shows localization to plasma membrane & cell junctions.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/36348/1320_A1_2_selected.jpg
Normal Tissue
Figure 2 Placenta
Cytotrophoblasts Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2422/6213_A_2_7.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5258/19792_B_9_5.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2422/6213_A_7_3.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (CAPAN-2, HaCaT, HBEC3-KT, hTCEpi, RT4)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000132470-ITGB4
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ITGB4
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Integrin subunit beta 4
- Biological Process
- Cell adhesion
- Molecular Function
- Integrin, Receptor
- Cellular Localization
- Plasma membrane, Cell Junctions
- Introduction
- Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
- Alternative Names
- CD104
- Gene ID
- 3691
- UniProt ID
- P16144
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "ITGB4"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0300MZ | Chicken Anti-ITGB4 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1602CQ | Recombinant Mouse Anti-ITGB4 Antibody (UM-A9) | FC, ICC, IF, BL | IgG2a, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1886 | Hi-Affi™ Recombinant Rabbit Anti-ITGB4 Monoclonal Antibody (DS1886AB) | WB, ICC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0855-CN | Recombinant Rabbit Anti-ITGB4 Monoclonal Antibody (JM11-06) | WB, IHC | Rabbit IgG |
| FN-067CQ | Recombinant Mouse Anti-ITGB4 Antibody (UMA9) | FC, FuncS, WB | Mouse IgG2a |
| HPAB-1275-FY | Human Anti-ITGB4 Recombinant Antibody (clone L001) | IHC, FC | Human IgG |
| ZG-0995F | Mouse Anti-ITGB4 Recombinant Antibody (clone 58XB4) | ELISA, FC, IF, IHC-Fr, IP, WB, ICC | Mouse IgG2a |
| VS3-WK552 | Rabbit Anti-ITGB4 Recombinant Antibody (clone JM11-06) | WB, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1275-FY-F(E) | Human Anti-ITGB4 Recombinant Antibody (clone L001); scFv Fragment | IHC, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1275-FY-S(P) | Human Anti-ITGB4 Recombinant Antibody (clone L001); Fab Fragment | IHC, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1159 | Anti-ITGB4 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3663 | Anti-Mouse ITGB4 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3664 | Anti-Human ITGB4 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3665 | Anti-Rat ITGB4 Immunohistochemistry Kit | IHC |
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