Recombinant Anti-JAM3 Vesicular Antibody, EV Displayed (VS-0425-YC324) (CAT#: VS-0425-YC324)

The Recombinant Anti-JAM3 Vesicular Antibody, EV Displayed (VS-0425-YC324) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to JAM3-expressed cells or tissues. The JAM3 is a tight junction protein in endothelial cells and is implicated in brain and eye disorders, forming weak homotypic interactions.

Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Recombinant Antibody

  • Application
  • Block, ELISA, FC, Cell-uptake
  • Product Type
  • Ab-Fc-EVs
  • Antibody Quantification (Ab/EV)
  • ~100 Ab/EV
  • Target
  • JAM3
  • Host Animal
  • Rat
  • Antibody Isotype
  • IgG
  • Species Reactivity
  • Human, Mouse
  • Expression Cell
  • Mammalian cell

Engineered EVs

  • EV-sorting domain
  • CD63
  • Fc-binding domain
  • Protein A
  • EV Size
  • 30~150 nm
  • Producing Cell
  • HEK293F
  • Isolation Method
  • Gradient centrifugation
  • Purification
  • qEV size exclusion chromatography
  • Concentration
  • 1 x 10¹⁰
  • Size
  • 1 mL
  • Buffer
  • PBS
  • Storage
  • Store at -80°C for 12 months

Target

  • Full Name
  • Junctional adhesion molecule 3
  • Biological Process
  • Angiogenesis, Cell adhesion, Differentiation, Spermatogenesis
  • Cellular Localization
  • Golgi apparatus
  • Introduction
  • Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts.
  • Alternative Names
  • JAM-3, JAM-C, JAMC

Downloads

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See other products for "JAM3"

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CAT Product Name Application Type
MOB-2270z Mouse Anti-JAM3 Recombinant Antibody (clone 13B3) ICC, IF, IHC, IP, FuncS Mouse IgG2a
MOB-2151MZ Recombinant Mouse Anti-Human JAM3 Antibody (clone NN0537-5N46) Neut, WB Mouse antibody
HPAB-0087-WJ Mouse Anti-JAM3 Recombinant Antibody (HPAB-0087-WJ) WB, ELISA, FC, SPR, IF, Inhib Mouse IgG1
VS3-FY782 Recombinant Mouse Anti-JAM3 Antibody (clone 2A5B6) ELISA, WB, FC Mouse IgG1

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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