Recombinant Anti-JAM3 Vesicular Antibody, EV Displayed (VS-0425-YC324) (CAT#: VS-0425-YC324)
The Recombinant Anti-JAM3 Vesicular Antibody, EV Displayed (VS-0425-YC324) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to JAM3-expressed cells or tissues. The JAM3 is a tight junction protein in endothelial cells and is implicated in brain and eye disorders, forming weak homotypic interactions.

(Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3417/if_selected.jpg

(Immunofluorescent staining of human cell line RH-30 shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50434/if_selected.jpg

(Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells in seminiferus ducts and leydig cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3417/ihc_selected.jpg

(Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3417/10082_B_7_5.jpg

(Endothelial cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3417/10082_A_9_3.jpg

(Hepatocytes
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3417/10082_A_7_4.jpg

(Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3417/10082_A_8_5.jpg

(Decidual cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
Trophoblastic cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3417/10082_A_2_7.jpg

(Non-germinal center cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3417/10082_A_9_8.jpg

(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000166086-JAM3
Recombinant Antibody
- Application
- Block, ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- JAM3
- Host Animal
- Rat
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Junctional adhesion molecule 3
- Biological Process
- Angiogenesis, Cell adhesion, Differentiation, Spermatogenesis
- Cellular Localization
- Golgi apparatus
- Introduction
- Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts.
- Alternative Names
- JAM-3, JAM-C, JAMC
- Gene ID
- 83700
- UniProt ID
- Q9BX67
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "JAM3"
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-2270z | Mouse Anti-JAM3 Recombinant Antibody (clone 13B3) | ICC, IF, IHC, IP, FuncS | Mouse IgG2a |
MOB-2151MZ | Recombinant Mouse Anti-Human JAM3 Antibody (clone NN0537-5N46) | Neut, WB | Mouse antibody |
HPAB-0087-WJ | Mouse Anti-JAM3 Recombinant Antibody (HPAB-0087-WJ) | WB, ELISA, FC, SPR, IF, Inhib | Mouse IgG1 |
VS3-FY782 | Recombinant Mouse Anti-JAM3 Antibody (clone 2A5B6) | ELISA, WB, FC | Mouse IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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