Recombinant Anti-LAIR1 Vesicular Antibody, EV Displayed (VS-0425-YC743)
CAT#: VS-0425-YC743
The Recombinant Anti-LAIR1 Vesicular Antibody, EV Displayed (VS-0425-YC743) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to LAIR1-expressed cells or tissues. LAIR1 is an inhibitory receptor found on immune cells, regulating responses to prevent self-cell lysis. It's linked to tyrosine phosphatase SHP-1 and may induce leukemia cell death.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11155/85_D9_2_selected.jpg
Normal Tissue
Figure 2 IHC staining of human lymph node
High expression. RNA expression: 5.8 nTPM
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11155/ihc_selected.jpg
Normal Tissue
Figure 3 IHC staining of human pancreas
Low expression. RNA expression: 3.8 nTPM
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11155/29172_A_3_3_val_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranou
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11155/29172_B_7_5.jpg
Normal Tissue
Figure 5 Colon
Peripheral nerve/ganglion
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11155/29172_A_8_3.jpg
Normal Tissue
Figure 6 Bone marrow
Hematopoietic cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11155/29172_B_5_4.jpg
RNA Expression
Figure 7 RNA cell line category: Group enriched (HMC-1, Karpas-707, THP-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167613-LAIR1
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- LAIR1
- Host Animal
- Human
- Antibody Isotype
- IgG1
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Leukocyte associated immunoglobulin like receptor 1
- Biological Process
- Adaptive immunity, Immunity
- Molecular Function
- Receptor
- Cellular Localization
- Plasma membrane
- Introduction
- The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias.
- Alternative Names
- CD305, LAIR-1
- Gene ID
- 3903
- UniProt ID
- Q6GTX8
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Datasheet
MSDS
COA
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2366z-S(P) | Recombinant Anti-Human LAIR1 Antibody scFv Fragment | ELISA, WB, FuncS | scFv |
| FAMAB-0229WJ-S(P) | Human Anti-LAIR1 Recombinant Antibody (clone MGE9); scFv Fragment | ELISA, WB | Human scFv |
| FAMAB-0230WJ-S(P) | Human Anti-LAIR1 Recombinant Antibody (clone MGF21); scFv Fragment | ELISA, WB | Human scFv |
| FAMAB-0231WJ-S(P) | Human Anti-LAIR1 Recombinant Antibody (clone MGO3); scFv Fragment | ELISA, WB | Human scFv |
| FAMAB-0232WJ-S(P) | Human Anti-LAIR1 Recombinant Antibody (clone MGQ4); scFv Fragment | ELISA, WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1768MZ | Recombinant Mouse Anti-Human LAIR1 Antibody (clone md23) | ELISA, FC, IHC-P, WB | Mouse antibody |
| FN-150CQ | Recombinant Armenian hamster Anti-LAIR1 Antibody (CBL-1314) | FC, FuncS, IP, WB | Armenian hamster IgG |
| FAMAB-0229WJ | Human Anti-LAIR1 Recombinant Antibody (clone MGE9) | ELISA, WB | Human IgG1 |
| FAMAB-0231WJ | Human Anti-LAIR1 Recombinant Antibody (clone MGO3) | ELISA, WB | Human IgG1 |
| FAMAB-0232WJ | Human Anti-LAIR1 Recombinant Antibody (clone MGQ4) | ELISA, WB | Human IgG3 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0320MZ | Chicken Anti-LAIR1 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4057 | Hi-Affi™ Recombinant Rabbit Anti-LAIR1 Monoclonal Antibody (SI124DS) | ELISA | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0230WJ | Human Anti-LAIR1 Recombinant Antibody (clone MGF21) | ELISA, WB | Human IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3912 | Anti-LAIR1 Immunohistochemistry Kit | IHC |
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