Recombinant Anti-LEPR Vesicular Antibody, EV Displayed (VS-0425-YC627)
CAT#: VS-0425-YC627
The Recombinant Anti-LEPR Vesicular Antibody, EV Displayed (VS-0425-YC627) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to LEPR-expressed cells or tissues. LEPR is a receptor for leptin, regulating body weight and fat metabolism. Mutations link to obesity and pituitary dysfunction.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IHC staining of human choroid plexus
Immunohistochemical staining of human choroid plexus shows strong membranous positivity in the ependymal cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/ih_additional_tissue/30899/975_429_400x400.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (K-562, RPTEC TERT1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000116678-LEPR
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- LEPR
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Leptin receptor
- Molecular Function
- Receptor
- Cellular Localization
- Vesicles, Plasma membrane, Primary cilium, Basal body, Cytosol
- Introduction
- The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction.
- Alternative Names
- CD295, OBR
- Gene ID
- 3953
- UniProt ID
- P48357
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Datasheet
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COA
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See other products for "LEPR"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-618-F(E) | Recombinant Human Anti-human LEPR Antibody Fab Fragment | RIA, IP, FuncS | Fab |
| HPAB-0132-YC-F(E) | Human Anti-LEPR Recombinant Antibody; Fab Fragment (HPAB-0132-YC-F(E)) | ELISA, FC | Human Fab |
| HPAB-0133-YC-F(E) | Human Anti-LEPR Recombinant Antibody; Fab Fragment (HPAB-0133-YC-F(E)) | ELISA, FC | Human Fab |
| HPAB-0134-YC-F(E) | Human Anti-LEPR Recombinant Antibody; Fab Fragment (HPAB-0134-YC-F(E)) | ELISA, FC | Human Fab |
| HPAB-0135-YC-F(E) | Human Anti-LEPR Recombinant Antibody; Fab Fragment (HPAB-0135-YC-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2037 | Hi-Affi™ Recombinant Rabbit Anti-LEPR Monoclonal Antibody (DS2037AB) | FC, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0132-YC | Human Anti-LEPR Recombinant Antibody (HPAB-0132-YC) | ELISA, FC | Human IgG |
| HPAB-0133-YC | Human Anti-LEPR Recombinant Antibody (HPAB-0133-YC) | ELISA, FC | Human IgG |
| HPAB-0134-YC | Human Anti-LEPR Recombinant Antibody (HPAB-0134-YC) | ELISA, FC | Human IgG |
| HPAB-0135-YC | Human Anti-LEPR Recombinant Antibody (HPAB-0135-YC) | ELISA, FC | Human IgG |
| VS3-CJ34 | Mouse Anti-LEPR Recombinant Antibody (VS3-CJ34) | WB, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0132-YC-S(P) | Human Anti-LEPR Recombinant Antibody; scFv Fragment (HPAB-0132-YC-S(P)) | ELISA, FC | Human scFv |
| HPAB-0133-YC-S(P) | Human Anti-LEPR Recombinant Antibody; scFv Fragment (HPAB-0133-YC-S(P)) | ELISA, FC | Human scFv |
| HPAB-0134-YC-S(P) | Human Anti-LEPR Recombinant Antibody; scFv Fragment (HPAB-0134-YC-S(P)) | ELISA, FC | Human scFv |
| HPAB-0135-YC-S(P) | Human Anti-LEPR Recombinant Antibody; scFv Fragment (HPAB-0135-YC-S(P)) | ELISA, FC | Human scFv |
| HPAB-N0167-YC-S(P) | Human Anti-LEPR Recombinant Antibody (HPAB-N0167-YC-S(P)); scFv Fragment | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3987 | Anti-LEPR Immunohistochemistry Kit | IHC | |
| VS-0525-XY3988 | Anti-Mouse LEPR Immunohistochemistry Kit | IHC |
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