Recombinant Anti-MED23 Vesicular Antibody, EV Displayed (VS-0425-YC392)
CAT#: VS-0425-YC392
The Recombinant Anti-MED23 Vesicular Antibody, EV Displayed (VS-0425-YC392) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to MED23-expressed cells or tissues. The MED23 is a protein implicated in gene transcription activation, acting within complexes regulating transcriptional initiation, and includes metastasis suppressor functions.
Gene Expression
RNA Expression
Figure 2 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000112282-MED23
Subcellular Location
Figure 1 IF staining of human cell line HaCaT
Immunofluorescent staining of human cell line HaCaT shows localization to nucleoplasm & vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70341/1324_H10_2_selected.jpg
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- MED23
- Host Animal
- Human
- Antibody Isotype
- IgG1
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Mediator complex subunit 23
- Biological Process
- Transcription, Transcription regulation
- Molecular Function
- Activator
- Cellular Localization
- Nucleoplasm, Vesicles
- Introduction
- The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2012]
- Alternative Names
- CRSP130, CRSP3, DRIP130, MRT18, Sur2
- Gene ID
- 9439
- UniProt ID
- Q9ULK4
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Datasheet
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COA
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See other products for "MED23"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABS-0280 | Camelid Anti-MED23 Recombinant Antibody (clone Nb106) | IP, ELISA | Camelid VHH |
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