Recombinant Anti-MMP16 Vesicular Antibody, EV Displayed (VS-0425-YC669)
CAT#: VS-0425-YC669
The Recombinant Anti-MMP16 Vesicular Antibody, EV Displayed (VS-0425-YC669) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to MMP16-expressed cells or tissues. MMP16 is a matrix metalloproteinase involved in extracellular matrix breakdown in processes like development and metastasis. It activates MMP2 by cleavage, and was formerly known as MT-MMP2.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23693/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human hippocampus
Immunohistochemical staining of human hippocampus shows moderate cytoplasmic positivity in neuronal cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23693/51539_B_8_6_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23693/51539_B_9_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23693/51539_A_9_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23693/51539_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23693/51539_A_4_6.jpg
Normal Tissue
Figure 7 Heart muscle
Cardiomyocytes Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23693/51539_B_5_6.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (AN3-CA, HUVEC TERT2, SH-SY5Y, U-138 MG, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000156103-MMP16
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- MMP16
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Matrix metallopeptidase 16
- Biological Process
- Collagen degradation
- Molecular Function
- Hydrolase, Metalloprotease, Protease
- Cellular Localization
- Cytosol, Vesicles
- Introduction
- Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. [provided by RefSeq, Oct 2010]
- Alternative Names
- C8orf57, DKFZp761D112, MT3-MMP
- Gene ID
- 4325
- UniProt ID
- P51512
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Datasheet
MSDS
COA
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See other products for "MMP16"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0371MZ | Chicken Anti-MMP16 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
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| MOR-4650 | Hi-Affi™ Recombinant Rabbit Anti-MMP16 Monoclonal Antibody (TH163DS) | WB, IF, ICC, IHC-P, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0030-DJB | Mouse Anti-MMP16 Recombinant Antibody (clone SC73.6) | ELISA, FC | Mouse IgG2a |
| HPAB-0031-DJB | Human Anti-MMP16 Recombinant Antibody (clone hSC73.38ss1) | ELISA, FC | Humanized IgG |
| HPAB-0032-DJB | Human Anti-MMP16 Recombinant Antibody (clone hSC73.39v1) | ELISA, FC | Humanized IgG |
| HPAB-0033-DJB | Mouse Anti-MMP16 Recombinant Antibody (HPAB-0033-DJB) | ELISA, FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0030-DJB-S(P) | Mouse Anti-MMP16 Recombinant Antibody (clone SC73.6); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-0031-DJB-S(P) | Human Anti-MMP16 Recombinant Antibody (clone hSC73.38ss1); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-0032-DJB-S(P) | Human Anti-MMP16 Recombinant Antibody (clone hSC73.39v1); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-0033-DJB-S(P) | Mouse Anti-MMP16 Recombinant Antibody; scFv Fragment (HPAB-0033-DJB-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0030-DJB-F(E) | Mouse Anti-MMP16 Recombinant Antibody (clone SC73.6); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-0031-DJB-F(E) | Human Anti-MMP16 Recombinant Antibody (clone hSC73.38ss1); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-0032-DJB-F(E) | Human Anti-MMP16 Recombinant Antibody (clone hSC73.39v1); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-0033-DJB-F(E) | Mouse Anti-MMP16 Recombinant Antibody; Fab Fragment (HPAB-0033-DJB-F(E)) | ELISA, FC | Mouse Fab |
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