Recombinant Anti-PECAM1 Vesicular Antibody, EV Displayed (VS-0425-YC719) (CAT#: VS-0425-YC719)
The Recombinant Anti-PECAM1 Vesicular Antibody, EV Displayed (VS-0425-YC719) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to PECAM1-expressed cells or tissues. PECAM1 is a protein found on platelets and several immune cells, comprising much of the endothelial cell intercellular junctions. Part of the immunoglobulin superfamily, it's involved in leukocyte migration, angiogenesis, and integrin activation.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line THP-1
(Immunofluorescent staining of human cell line THP-1 shows localization to nucleoli & plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4871/2005_B3_2_selected.jpg
(Immunofluorescent staining of human cell line THP-1 shows localization to nucleoli & plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4871/2005_B3_2_selected.jpg
Figure 2 Lung
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4690/13163_A_2_4_val_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4690/13163_A_2_4_val_selected.jpg
Figure 3 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4690/13163_B_8_5.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4690/13163_B_8_5.jpg
Figure 4 Colon
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4690/13163_A_9_3.jpg
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4690/13163_A_9_3.jpg
Figure 5 Kidney
(Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4690/13163_A_8_5.jpg
(Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4690/13163_A_8_5.jpg
Figure 6 RNA cell line category: Group enriched (HUVEC TERT2, TIME)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000261371-PECAM1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000261371-PECAM1
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- PECAM1
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Mouse, Rabbit
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Platelet and endothelial cell adhesion molecule 1
- Biological Process
- Cell adhesion, Phagocytosis
- Cellular Localization
- Nucleoli, Plasma membrane
- Introduction
- The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation.
- Alternative Names
- CD31
- Gene ID
- 5175
- UniProt ID
- P16284
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1852CQ | Recombinant Mouse Anti-PECAM1 Antibody (HEC7) | BL, ELISA, FC, ICC/IF, IHC, IP, WB | IgG2a |
| NEUT-1855CQ | Recombinant Mouse Anti-PECAM1 Antibody (WM59) | FC, IHC, IF, BL | IgG1, κ |
| NEUT-1856CQ | Recombinant Rat Anti-Pecam1 Antibody (390) | FC, IP, IHC-Fr, ICC, BL | IgG2a, κ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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