Recombinant Anti-PIGR Vesicular Antibody, EV Displayed (VS-0425-YC535) (CAT#: VS-0425-YC535)
The Recombinant Anti-PIGR Vesicular Antibody, EV Displayed (VS-0425-YC535) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to PIGR-expressed cells or tissues. PIGR is a poly-Ig receptor that binds polymeric immunoglobulins at epithelial surfaces, transporting them for secretion. SNPs in PIGR are associated with immunoglobulin A nephropathy.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Kidney
(Bowman's capsule Staining: Medium Intensity: Strong Quantity: <25% Collecting ducts Staining: High Intensity: Strong Quantity: 75%-25% Distal tubules Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12012/28150_A_7_5.jpg
(Bowman's capsule Staining: Medium Intensity: Strong Quantity: <25% Collecting ducts Staining: High Intensity: Strong Quantity: 75%-25% Distal tubules Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12012/28150_A_7_5.jpg
Figure 2 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12012/28150_A_6_6.jpg
(Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12012/28150_A_6_6.jpg
Figure 3 High expression in colon
(Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Microvilli Staining: High Intensity: Strong Goblet cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12012/28150_A_9_3.jpg
(Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Microvilli Staining: High Intensity: Strong Goblet cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12012/28150_A_9_3.jpg
Figure 4 Liver
(Hepatocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12012/28150_A_9_4.jpg
(Hepatocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12012/28150_A_9_4.jpg
Figure 5 Gallbladder
(Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12012/28150_A_4_4.jpg
(Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12012/28150_A_4_4.jpg
Figure 6 RNA cell line category: Cell line enriched (EFO-21)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000162896-PIGR
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000162896-PIGR
Recombinant Antibody
- Application
- Antagonist, Cyt, ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- PIGR
- Host Animal
- Human
- Antibody Isotype
- IgG1
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Polymeric immunoglobulin receptor
- Introduction
- This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009]
- Gene ID
- 5284
- UniProt ID
- P01833
Downloads
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IgG Antibody Products
Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2531z | Mouse Anti-PIGR Recombinant Antibody (clone 3C8) | WB, ELISA, IHC | Mouse IgG1 |
| HPAB-0923-YJ | Camelid Anti-PIGR Recombinant Antibody (clone 1D2) | ELISA, Antagonist, IF, IP, Transcytosis capacity | Camelid VHH |
| HPAB-0924-YJ | Camelid Anti-PIGR Recombinant Antibody (clone 1E7) | ELISA, Antagonist, IF | Camelid VHH |
| VS7-0425-WR610 | Mouse Anti-PIGR Recombinant Antibody (clone 6E5A9) | IHC | Mouse IgG1 |
| VS7-0425-WR611 | Mouse Anti-PIGR Recombinant Antibody (clone 1E2B12) | IHC | Mouse IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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