Recombinant Anti-PIGR Vesicular Antibody, EV Displayed (VS-0425-YC535) (CAT#: VS-0425-YC535)
The Recombinant Anti-PIGR Vesicular Antibody, EV Displayed (VS-0425-YC535) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to PIGR-expressed cells or tissues. PIGR is a poly-Ig receptor that binds polymeric immunoglobulins at epithelial surfaces, transporting them for secretion. SNPs in PIGR are associated with immunoglobulin A nephropathy.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Kidney
(Bowman's capsule Staining: Medium Intensity: Strong Quantity: <25% Collecting ducts Staining: High Intensity: Strong Quantity: 75%-25% Distal tubules Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12012/28150_A_7_5.jpg
(Bowman's capsule Staining: Medium Intensity: Strong Quantity: <25% Collecting ducts Staining: High Intensity: Strong Quantity: 75%-25% Distal tubules Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12012/28150_A_7_5.jpg
Figure 2 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12012/28150_A_6_6.jpg
(Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12012/28150_A_6_6.jpg
Figure 3 High expression in colon
(Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Microvilli Staining: High Intensity: Strong Goblet cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12012/28150_A_9_3.jpg
(Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Microvilli Staining: High Intensity: Strong Goblet cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12012/28150_A_9_3.jpg
Figure 4 Liver
(Hepatocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12012/28150_A_9_4.jpg
(Hepatocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12012/28150_A_9_4.jpg
Figure 5 Gallbladder
(Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12012/28150_A_4_4.jpg
(Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12012/28150_A_4_4.jpg
Figure 6 RNA cell line category: Cell line enriched (EFO-21)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000162896-PIGR
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000162896-PIGR
Recombinant Antibody
- Application
- Antagonist, Cyt, ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- PIGR
- Host Animal
- Human
- Antibody Isotype
- IgG1
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Polymeric immunoglobulin receptor
- Introduction
- This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009]
- Gene ID
- 5284
- UniProt ID
- P01833
Downloads
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IgG Antibodies
Rabbit Monoclonal Antibodies
IHC Kits & Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2531z | Mouse Anti-PIGR Recombinant Antibody (clone 3C8) | WB, ELISA, IHC | Mouse IgG1 |
| HPAB-0923-YJ | Camelid Anti-PIGR Recombinant Antibody (clone 1D2) | ELISA, Antagonist, IF, IP, Transcytosis capacity | Camelid VHH |
| HPAB-0924-YJ | Camelid Anti-PIGR Recombinant Antibody (clone 1E7) | ELISA, Antagonist, IF | Camelid VHH |
| VS7-0425-WR610 | Mouse Anti-PIGR Recombinant Antibody (clone 6E5A9) | IHC | Mouse IgG1 |
| VS7-0425-WR611 | Mouse Anti-PIGR Recombinant Antibody (clone 1E2B12) | IHC | Mouse IgG1 |
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