Recombinant Anti-RHD Vesicular Antibody, EV Displayed (VS-0425-YC245)
CAT#: VS-0425-YC245
The Recombinant Anti-RHD Vesicular Antibody, EV Displayed (VS-0425-YC245) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to RHD-expressed cells or tissues. The RHD is part of the Rh blood group system, encoding the RhD protein, determining Rh classification. Multiple transcript variants exist.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Group enriched (HEL, K-562)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000187010-RHD
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Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- RHD
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Rh blood group D antigen
- Molecular Function
- Blood group antigen
- Cellular Localization
- Nucleoplasm, Plasma membrane
- Introduction
- The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene, which encodes the RhD protein, and a second gene that encodes both the RhC and RhE antigens on a single polypeptide. The two genes, and a third unrelated gene, are found in a cluster on chromosome 1. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. Multiple transcript variants encoding different isoforms have been found for this gene.
- Alternative Names
- CD240D, DIIIc, RH, Rh30a, Rh4, RhII, RhPI
- Gene ID
- 6007
- UniProt ID
- Q02161
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Datasheet
MSDS
COA
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