Recombinant Anti-SCN8A Vesicular Antibody, EV Displayed (VS-0425-YC53) (CAT#: VS-0425-YC53)

• Application
• ELISA, FC, Cell-uptake

• Product Type
• Ab-Fc-EVs

• Antibody Quantification (Ab/EV)
• ~100 Ab/EV

• Target
• SCN8A

• Host Animal
• Rabbit

• Antibody Isotype
• IgG

• Species Reactivity
• Human, Mouse, Rat

• Expression Cell
• Mammalian cell

• EV-sorting domain
• CD63

• Fc-binding domain
• Protein A

• EV Size
• 30~150 nm

• Producing Cell
• HEK293F

• Isolation Method
• Gradient centrifugation

• Purification
• qEV size exclusion chromatography

• Concentration
• 1 x 10¹⁰

• Size
• 1 mL

• Buffer
• PBS

• Storage
• Store at -80°C for 12 months

• Full Name
• Sodium voltage-gated channel alpha subunit 8

• Biological Process
• Ion transport, Sodium transport, Transport

• Molecular Function
• Ion channel, Sodium channel, Voltage-gated channel

• Cellular Localization
• Plasma membrane, Vesicles, Cell Junctions

• Introduction
• This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with cognitive disability, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.

• Alternative Names
• CerIII, CIAT, MED, NaCh6, Nav1.6, PN4

• Gene ID
• 6334

• UniProt ID
• Q9UQD0

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