Recombinant Anti-SIRPB1 Vesicular Antibody, EV Displayed (VS-0425-YC716)
CAT#: VS-0425-YC716
The Recombinant Anti-SIRPB1 Vesicular Antibody, EV Displayed (VS-0425-YC716) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to SIRPB1-expressed cells or tissues. SIRPB1 is a member of the signal-regulatory-protein family and the immunoglobulin superfamily, acting as a receptor-type transmembrane glycoprotein. It's involved in the negative regulation of receptor tyrosine kinase signaling, interacting with TYROBP/DAP12 and recruiting tyrosine kinase SYK. Multiple transcript variants exist.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line SK-MEL-30
Immunofluorescent staining of human cell line SK-MEL-30 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47463/1262_E2_1_selected.jpg
Normal Tissue
Figure 2 IHC staining of human heart muscle
Immunohistochemical staining of human heart muscle shows strong cytoplasmic positivity in myocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47463/ihc_selected.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47463/117489_A_8_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47463/117489_A_8_4.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47463/117489_A_4_6.jpg
Normal Tissue
Figure 6 Appendix
Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47463/117489_A_2_2.jpg
RNA Expression
Figure 7 RNA cell line category: Group enriched (HMC-1, NB-4, THP-1)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000101307-SIRPB1
❮
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Recombinant Antibody
- Application
- ELISA, FC, SPR, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- SIRPB1
- Host Animal
- Rabbit
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Signal regulatory protein beta 1
- Cellular Localization
- Vesicles, Centrosome
- Introduction
- The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
- Alternative Names
- CD172b, SIRP-BETA-1
- Gene ID
- 10326
- UniProt ID
- O00241, Q5TFQ8
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "SIRPB1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1382CT | Recombinant Mouse anti-Human SIRPB1 Monoclonal antibody (EML750) | FC, IP, WB | |
| FAMAB-1256CQ | Rabbit Anti-SIRPB1 Recombinant Antibody (clone OX130) | SPR, ELISA, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3266 | Hi-Affi™ Recombinant Rabbit Anti-SIRPB1 Monoclonal Antibody (DS3266AB) | ELISA, WB | IgG |
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