Recombinant Anti-SIRPG Vesicular Antibody, EV Displayed (VS-0425-YC714)

CAT#: VS-0425-YC714

The Recombinant Anti-SIRPG Vesicular Antibody, EV Displayed (VS-0425-YC714) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to SIRPG-expressed cells or tissues. SIRPG is a signal-regulatory protein that negatively regulates tyrosine kinase-coupled signaling.

Gene Expression
Figure 1 RNA cell line category: Cell line enhanced (hTERT-RPE1, JURKAT, NB-4, RT4, THP-1)

Recombinant Antibody

  • Application
  • ELISA, FC, Cell-uptake
  • Product Type
  • Ab-Fc-EVs
  • Antibody Quantification (Ab/EV)
  • ~100 Ab/EV
  • Target
  • SIRPG
  • Host Animal
  • Human
  • Antibody Isotype
  • IgG
  • Species Reactivity
  • Human
  • Expression Cell
  • Mammalian cell

Engineered EVs

  • EV-sorting domain
  • CD63
  • Fc-binding domain
  • z domain
  • EV Size
  • 30~150 nm
  • Producing Cell
  • HEK293F
  • Isolation Method
  • Gradient centrifugation
  • Purification
  • qEV size exclusion chromatography
  • Binding Affinity
  • Kd = 0.85 µg/mL
  • Concentration
  • 1 x 10¹⁰
  • Size
  • 1 mL
  • Buffer
  • PBS
  • Storage
  • Store at -80°C for 12 months

Target

  • Full Name
  • Signal regulatory protein gamma
  • Biological Process
  • Cell adhesion
  • Introduction
  • The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described.
  • Alternative Names
  • bA77C3.1, CD172g, SIRP-B2, SIRPB2, SIRPgamma
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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