Recombinant Anti-SORT1 Vesicular Antibody, EV Displayed (VS-0425-YC454) (CAT#: VS-0425-YC454)
The Recombinant Anti-SORT1 Vesicular Antibody, EV Displayed (VS-0425-YC454) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to SORT1-expressed cells or tissues. The SORT1 is a receptor involved in protein trafficking and myocardial infarction risk.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/if_selected.jpg
Figure 2 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11498/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11498/if_selected.jpg
Figure 3 Hippocampal formation
(High expression in hippocampal formation)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/18321_B_8_6_val_selected.jpg
(High expression in hippocampal formation)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/18321_B_8_6_val_selected.jpg
Figure 4 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Sertoli cells Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/18321_A_6_6.jpg
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Sertoli cells Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/18321_A_6_6.jpg
Figure 5 Lymph node
(Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/18321_A_8_8.jpg
(Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/18321_A_8_8.jpg
Figure 6 Hippocampus
(Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/18321_B_8_6.jpg
(Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/18321_B_8_6.jpg
Figure 7 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/18321_A_7_3.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/18321_A_7_3.jpg
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000134243-SORT1
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000134243-SORT1
Recombinant Antibody
- Application
- Block, ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- SORT1
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Sortilin 1
- Biological Process
- Differentiation, Endocytosis, Osteogenesis, Transport
- Molecular Function
- Developmental protein, Receptor
- Cellular Localization
- Golgi apparatus, Cytosol, Plasma membrane
- Introduction
- This gene encodes a member of the VPS10-related sortilin family of proteins. The encoded preproprotein is proteolytically processed by furin to generate the mature receptor. This receptor plays a role in the trafficking of different proteins to either the cell surface, or subcellular compartments such as lysosomes and endosomes. Expression levels of this gene may influence the risk of myocardial infarction in human patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
- Alternative Names
- Gp95, NT3
- Gene ID
- 6272
- UniProt ID
- Q99523
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1378LY-S(P) | Human Anti-SORT1 Recombinant Antibody; scFv Fragment (HPAB-1378LY-S(P)) | Inhib, FC, ELISA | Humanized scfv |
| HPAB-1379LY-S(P) | Human Anti-SORT1 Recombinant Antibody; scFv Fragment (HPAB-1379LY-S(P)) | Inhib, FC, ELISA | Humanized scfv |
| HPAB-1380LY-S(P) | Human Anti-SORT1 Recombinant Antibody; scFv Fragment (HPAB-1380LY-S(P)) | Inhib, FC, ELISA | Humanized scfv |
| HPAB-1381LY-S(P) | Human Anti-SORT1 Recombinant Antibody; scFv Fragment (HPAB-1381LY-S(P)) | Inhib, FC, ELISA | Humanized scfv |
| HPAB-1382LY-S(P) | Human Anti-SORT1 Recombinant Antibody; scFv Fragment (HPAB-1382LY-S(P)) | Inhib, FC, ELISA | Humanized scfv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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