Recombinant Anti-SORT1 Vesicular Antibody, EV Displayed (VS-0425-YC454) (CAT#: VS-0425-YC454)

• Application
• Block, ELISA, FC, Cell-uptake

• Product Type
• Ab-Fc-EVs

• Antibody Quantification (Ab/EV)
• ~100 Ab/EV

• Target
• SORT1

• Host Animal
• Human

• Antibody Isotype
• IgG

• Species Reactivity
• Human, Mouse

• Expression Cell
• Mammalian cell

• EV-sorting domain
• CD63

• Fc-binding domain
• z domain

• EV Size
• 30~150 nm

• Producing Cell
• HEK293F

• Isolation Method
• Gradient centrifugation

• Purification
• qEV size exclusion chromatography

• Binding Affinity
• Kd = 0.85 µg/mL

• Concentration
• 1 x 10¹⁰

• Size
• 1 mL

• Buffer
• PBS

• Storage
• Store at -80°C for 12 months

• Full Name
• Sortilin 1

• Biological Process
• Differentiation, Endocytosis, Osteogenesis, Transport

• Molecular Function
• Developmental protein, Receptor

• Cellular Localization
• Golgi apparatus, Cytosol, Plasma membrane

• Introduction
• This gene encodes a member of the VPS10-related sortilin family of proteins. The encoded preproprotein is proteolytically processed by furin to generate the mature receptor. This receptor plays a role in the trafficking of different proteins to either the cell surface, or subcellular compartments such as lysosomes and endosomes. Expression levels of this gene may influence the risk of myocardial infarction in human patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

• Alternative Names
• Gp95, NT3

• Gene ID
• 6272

• UniProt ID
• Q99523

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