Recombinant Anti-SORT1 Vesicular Antibody, EV Displayed (VS-0425-YC454)
CAT#: VS-0425-YC454
The Recombinant Anti-SORT1 Vesicular Antibody, EV Displayed (VS-0425-YC454) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to SORT1-expressed cells or tissues. The SORT1 is a receptor involved in protein trafficking and myocardial infarction risk.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11498/if_selected.jpg
Normal Tissue
Figure 3 Hippocampal formation
High expression in hippocampal formation
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/18321_B_8_6_val_selected.jpg
Normal Tissue
Figure 4 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Sertoli cells Staining: Medium Intensity: Moderate Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/18321_A_6_6.jpg
Normal Tissue
Figure 5 Lymph node
Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/18321_A_8_8.jpg
Normal Tissue
Figure 6 Hippocampus
Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/18321_B_8_6.jpg
Normal Tissue
Figure 7 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6889/18321_A_7_3.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000134243-SORT1
❮
❯
Recombinant Antibody
- Application
- Block, ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- SORT1
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Sortilin 1
- Biological Process
- Differentiation, Endocytosis, Osteogenesis, Transport
- Molecular Function
- Developmental protein, Receptor
- Cellular Localization
- Golgi apparatus, Cytosol, Plasma membrane
- Introduction
- This gene encodes a member of the VPS10-related sortilin family of proteins. The encoded preproprotein is proteolytically processed by furin to generate the mature receptor. This receptor plays a role in the trafficking of different proteins to either the cell surface, or subcellular compartments such as lysosomes and endosomes. Expression levels of this gene may influence the risk of myocardial infarction in human patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
- Alternative Names
- Gp95, NT3
- Gene ID
- 6272
- UniProt ID
- Q99523
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Datasheet
MSDS
COA
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See other products for "SORT1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1383LY-S(P) | Human Anti-SORT1 Recombinant Antibody; scFv Fragment (HPAB-1383LY-S(P)) | Inhib, FC, ELISA | Humanized scfv |
| HPAB-1384LY-S(P) | Human Anti-SORT1 Recombinant Antibody; scFv Fragment (HPAB-1384LY-S(P)) | Inhib, FC, ELISA | Humanized scfv |
| HPAB-1385LY-S(P) | Human Anti-SORT1 Recombinant Antibody; scFv Fragment (HPAB-1385LY-S(P)) | Inhib, FC, ELISA | Humanized scfv |
| HPAB-1386LY-S(P) | Human Anti-SORT1 Recombinant Antibody; scFv Fragment (HPAB-1386LY-S(P)) | Inhib, FC, ELISA | Humanized scfv |
| HPAB-1387LY-S(P) | Human Anti-SORT1 Recombinant Antibody; scFv Fragment (HPAB-1387LY-S(P)) | Inhib, FC, ELISA | Humanized scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1378LY | Human Anti-SORT1 Recombinant Antibody (HPAB-1378LY) | Inhib, FC, ELISA | Humanized IgG |
| HPAB-1379LY | Human Anti-SORT1 Recombinant Antibody (HPAB-1379LY) | Inhib, FC, ELISA | Humanized IgG |
| HPAB-1380LY | Human Anti-SORT1 Recombinant Antibody (HPAB-1380LY) | Inhib, FC, ELISA | Humanized IgG |
| HPAB-1381LY | Human Anti-SORT1 Recombinant Antibody (HPAB-1381LY) | Inhib, FC, ELISA | Humanized IgG |
| HPAB-1382LY | Human Anti-SORT1 Recombinant Antibody (HPAB-1382LY) | Inhib, FC, ELISA | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1378LY-F(E) | Human Anti-SORT1 Recombinant Antibody; Fab Fragment (HPAB-1378LY-F(E)) | Inhib, FC, ELISA | Humanized Fab |
| HPAB-1379LY-F(E) | Human Anti-SORT1 Recombinant Antibody; Fab Fragment (HPAB-1379LY-F(E)) | Inhib, FC, ELISA | Humanized Fab |
| HPAB-1380LY-F(E) | Human Anti-SORT1 Recombinant Antibody; Fab Fragment (HPAB-1380LY-F(E)) | Inhib, FC, ELISA | Humanized Fab |
| HPAB-1381LY-F(E) | Human Anti-SORT1 Recombinant Antibody; Fab Fragment (HPAB-1381LY-F(E)) | Inhib, FC, ELISA | Humanized Fab |
| HPAB-1382LY-F(E) | Human Anti-SORT1 Recombinant Antibody; Fab Fragment (HPAB-1382LY-F(E)) | Inhib, FC, ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2146 | Anti-SORT1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6811 | Anti-Mouse SORT1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6810 | Anti-Human SORT1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6812 | Anti-Rat SORT1 Immunohistochemistry Kit | IHC |
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