Recombinant Anti-THBD Vesicular Antibody, EV Displayed (VS-0425-YC711) (CAT#: VS-0425-YC711)

• Application
• ELISA, FC, Cell-uptake

• Product Type
• Ab-Fc-EVs

• Antibody Quantification (Ab/EV)
• ~100 Ab/EV

• Target
• THBD

• Host Animal
• Human

• Antibody Isotype
• IgG

• Species Reactivity
• Rabbit, Human

• Expression Cell
• Mammalian cell

• EV-sorting domain
• CD63

• Fc-binding domain
• z domain

• EV Size
• 30~150 nm

• Producing Cell
• HEK293F

• Isolation Method
• Gradient centrifugation

• Purification
• qEV size exclusion chromatography

• Binding Affinity
• Kd = 0.85 µg/mL

• Concentration
• 1 x 10¹⁰

• Size
• 1 mL

• Buffer
• PBS

• Storage
• Store at -80°C for 12 months

• Full Name
• Thrombomodulin

• Biological Process
• Blood coagulation, Hemostasis

• Molecular Function
• Receptor

• Cellular Localization
• Nucleoplasm, Cytosol

• Introduction
• The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia.

• Alternative Names
• BDCA-3, CD141, THRM

• Gene ID
• 7056

• UniProt ID
• P07204

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