Recombinant Anti-THBD Vesicular Antibody, EV Displayed (VS-0425-YC711)
CAT#: VS-0425-YC711
The Recombinant Anti-THBD Vesicular Antibody, EV Displayed (VS-0425-YC711) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to THBD-expressed cells or tissues. THBD is an endothelial receptor binding thrombin, important for coagulation by activating protein C and associated with thromboembolic diseases.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2982/29_E4_2_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human placenta
Immunohistochemical staining of human placenta shows strong membranous positivity in trophoblastic cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2982/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IHC staining of human placenta
Immunohistochemical staining of human placenta shows luminal positivity.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2425/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 4 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2982/30_E4_1_red_green.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2425/6389_A_7_3.jpg
Normal Tissue
Figure 6 Placenta
Trophoblastic cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2425/6389_A_3_7.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (ASC diff, CAPAN-2, EFO-21, HaCaT, hTCEpi, OE19, THP-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000178726-THBD
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- THBD
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Rabbit, Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Thrombomodulin
- Biological Process
- Blood coagulation, Hemostasis
- Molecular Function
- Receptor
- Cellular Localization
- Nucleoplasm, Cytosol
- Introduction
- The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia.
- Alternative Names
- BDCA-3, CD141, THRM
- Gene ID
- 7056
- UniProt ID
- P07204
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Datasheet
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COA
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