Recombinant Anti-TRAC Vesicular Antibody, EV Displayed (VS-0425-YC710)
CAT#: VS-0425-YC710
The Recombinant Anti-TRAC Vesicular Antibody, EV Displayed (VS-0425-YC710) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to TRAC-expressed cells or tissues. TRAC is a T cell receptor components recognizing antigen presented by MHC molecules, integral to immune diversity through gene rearrangement.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (HDLM-2, JURKAT, NB-4, U-266/84, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000277734-TRAC
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- TRAC
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- T cell receptor alpha constant
- Biological Process
- Adaptive immunity, Immunity
- Molecular Function
- Receptor
- Introduction
- T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]
- Gene ID
- 28755
- UniProt ID
- P01848
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "TRAC"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0363MC | Recombinant Mouse Anti-TCR Alpha antibody | IHC, IP |
| CAT | Product Name | Application | Type |
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| MOB-025YJL | Mouse Anti-TRAC Recombinant Antibody (clone CB66YJ) | FC, IP, IHC-P, IHC-Fr, WB | Mouse IgG2a |
| CAT | Product Name | Application | Type |
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| FAMAB-1283CQ | Mouse Anti-TRAC Recombinant Antibody (clone 34) | WB, ELISA, FC | Mouse IgG1 |
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