Recombinant Anti-ZP3 Vesicular Antibody, EV Displayed (VS-0425-YC48)
CAT#: VS-0425-YC48
The Recombinant Anti-ZP3 Vesicular Antibody, EV Displayed (VS-0425-YC48) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ZP3-expressed cells or tissues. The ZP3 is a zona pellucida structural component essential for fertilization processes and the acrosome reaction.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IHC staining of human ovary
Immunohistochemical staining of human ovary shows strong cytoplasmic positivity in follicle cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54061/163601_A_6_7_selected.jpg
Normal Tissue
Figure 2 Ovary
Follicle cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54061/163601_A_6_7.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (A549, hTCEpi, Karpas-707, MCF7, OE19)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000188372-ZP3/subcellular
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ZP3
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Mouse, Rat
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Zona pellucida glycoprotein 3
- Biological Process
- Fertilization
- Molecular Function
- Receptor
- Introduction
- The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene.
- Alternative Names
- ZP3-372, ZP3-424, ZP3A, ZP3B, ZPC
- Gene ID
- 7784
- UniProt ID
- P21754
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Datasheet
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| CAT | Product Name | Application | Type |
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