ΗΡΤΡ-β
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Loading...- Human Anti-ΗΡΤΡ-β Recombinant Antibody (HPAB-N0306-YC) (HPAB-N0306-YC)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: FC, WB, Block
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- Human Anti-ΗΡΤΡ-β Recombinant Antibody; scFv Fragment (HPAB-N0306-YC-S(P)) (HPAB-N0306-YC-S(P))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: FC, WB, Block
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- Human Anti-ΗΡΤΡ-β Recombinant Antibody; Fab Fragment (HPAB-N0306-YC-F(E)) (HPAB-N0306-YC-F(E))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: FC, WB, Block
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For Research Use Only. Not For Clinical Use.
Background
Under physiological conditions, the duration of Tie-2 phosphorylation is regulated by the human protein tyrosine phosphatase beta (often abbreviated as ΗΡΤΡβ or HPTP beta), which removes the phosphate from the Tie-2 receptor. By inhibiting ΗΡΤΡβ, the level of Tie-2 phosphorylation substantially increases, restoring proper cell proximity. ΗΡΤΡβ plays a functional role in endothelial cell proliferation, viability, differentiation, vasculogenesis, and angiogenesis. ΗΡΤΡβ and vascular endothelial protein tyrosine phosphatase (VE-PTP; the mouse orthologue of ΗΡΤΡβ) are expressed in vascular endothelial cells throughout development.