α-GalCer (C16)
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Loading...- Bovine Anti-α-GalCer (C16) Recombinant Soluble TCR (clone YC61) (scTCR-1415YC-S(P))
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- Epitope: (2R,3S,4S)-1-O-(α-D-galactopyranosyl)-2-palmitoylamino-1,3,4-octadecanetriol
- MHC: CD1d
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- Epitope: (2R,3S,4S)-1-O-(α-D-galactopyranosyl)-2-palmitoylamino-1,3,4-octadecanetriol
- MHC: CD1d
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- Recombinant Bovine Anti-α-GalCer (C16) Soluble TCR (YC61) (C-Cys) (VS-0622-YF5412)
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- Epitope: (2R,3S,4S)-1-O-(α-D-galactopyranosyl)-2-palmitoylamino-1,3,4-octadecanetriol
- MHC: CD1d
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- Recombinant Bovine Anti-α-GalCer (C16) Soluble TCR (YC61) (KIH) (VS-0622-YF8120)
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- Epitope: (2R,3S,4S)-1-O-(α-D-galactopyranosyl)-2-palmitoylamino-1,3,4-octadecanetriol
- MHC: CD1d
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For Research Use Only. Not For Clinical Use.
Background
alpha-Galactosylceramide (α-GalCer, KRN7000) is a synthetic glycolipid derived from structure-activity relationship studies of galactosylceramides isolated from the marine sponge Agelas mauritianus. α-GalCer is a strong immunostimulant and shows potent anti-tumour activity in many in vivo models. α-GalCer is a potent activator of iNKT cells, and a model CD1d antigen. The invariant T cell receptor of the iNKT cell is able to bind the CD1d:glycolipid complex leading to iNKT cell in both mice and humans.