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αIIbβ3 integrin

Anti-αIIbβ3 integrin Products

RGD-containing proteins scaffold protein anti-Human αIIbβ3 (SRG-L254)
- Scaffold Name: RGD-containing proteins
- Target: αIIbβ3
- Species Reactivity: Human
- Derivation: Phage display
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For Research Use Only. Not For Clinical Use.

Background

In medicine, glycoprotein IIb/IIIa (GPIIb/IIIa, also known as integrin αIIbβ3) is an integrin complex found on platelets. It is a receptor for fibrinogen and von Willebrand factor and aids platelet activation. The complex is formed via calcium-dependent association of gpIIb and gpIIIa, a required step in normal platelet aggregation and endothelial adherence. Platelet activation by ADP (blocked by clopidogrel) leads to the aforementioned conformational change in platelet gpIIb/IIIa receptors that induces binding to fibrinogen. The gpIIb/IIIa receptor is a target of several drugs including abciximab, eptifibatide, tirofiban.