Anti-ABCC5 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs facilitates cancer research and cell signaling studies with our high-specificity anti-ABCC5 recombinant antibodies. The ABCC5 transporter moves cGMP and many drug metabolites across the plasma membrane, and is an exciting new target in cancer biology and homeostasis. Our top-quality antibodies will help you explore the importance of this efflux transporter in drug resistance and cGMP-mediated signaling.

ABCC5: An Efflux Transporter for cGMP and Drug Metabolites

The ATP-binding cassette subfamily C member 5 (ABCC5), also called Multidrug Resistance-Associated Protein 5 (MRP5), is an efflux transporter with a preference for the cyclic nucleotide substrate, cyclic guanosine monophosphate (cGMP). ABCC5 is a major determinant of intracellular cGMP levels and helps fine-tune physiological processes where this second messenger is the signal-transducer, such as smooth muscle relaxation and phototransduction. In addition to cGMP, ABCC5 transports a wide variety of glucuronidated drug metabolites, and is known to mediate resistance to certain anticancer drugs and antiviral nucleotides, such as 5-fluorouracil and PMEA (adefovir).

Alternative Names

ABCC5; Canalicular Multispecific Organic Anion Transporter C; Multidrug Resistance-Associated Protein 5; MRP5; SMRP; Multi-Specific Organic Anion Transporter C; ATP-Binding Cassette Sub-Family C Member 5; EST277145; PABC11; ATP-Binding Cassette, Sub-Famil

Background

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.

Anti-ABCC5 rAb Products

Creative Biolabs' anti-ABCC5 recombinant antibodies are designed for optimal specificity and performance. Each batch is thoroughly validated to detect ABCC5 in cell lines and tissues so you can explore this transporter's role in drug resistance and cGMP signaling. Optimized for Western Blot and IHC, these rAbs will deliver the sharp, specific signals you need for your research.

Table 1. Featured anti-ABCC5 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs uses proprietary production technologies to make the best possible research tools for cancer pharmacology researchers. Our anti-ABCC5 recombinant antibodies are produced in systems optimized for expression and folding, so the antibodies we make are well-equipped to recognize the native form of this membrane transporter with high specificity and activity.

Featured Anti-ABCC5 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-ABCC5 recombinant antibody production.

Fig.2 Gram-scale anti-ABCC5 recombinant antibody production.

rAb Modalities

Creative Biolabs advances the research enterprise by providing a full spectrum of antibody modalities. Our anti-ABCC5 antibodies are available as full-length IgGs for ELISA, Western blot, immunoprecipitation, and more, as well as engineered antibody fragments for challenging or specialized research.

Fig.3 Full-length anti-ABCC5 recombinant antibody production and modalities.

Study the functions of ABCC5 in cGMP signaling and drug resistance with high confidence and clear signals from Creative Biolabs' recombinant antibodies. Our portfolio is characterized by high specificity and stringent validation, ensuring the best tools for your research in oncology and cell biology. Contact our team of specialists today and partner with us for quality that drives discovery.