Anti-ABCC6 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is a premier provider of rare disease and cardiovascular research tools. We are proud to offer top-tier anti-ABCC6 recombinant antibodies for study of the transporter that is deficient in Pseudoxanthoma elasticum (PXE), an inherited disorder that causes ectopic calcification in tissues like the skin, eyes, and cardiovascular system.

ABCC6: The Transporter Deficient in Pseudoxanthoma Elasticum

ATP-binding cassette subfamily C member 6 (ABCC6), also known as MRP6, is a transporter that is found predominantly in the basolateral membrane of hepatocytes. ABCC6's primary physiological role is to transport ATP out of liver cells, where it is released into circulation. Extracellular ATP is then rapidly converted into pyrophosphate (PPi), an extracellular nucleotide that is a potent inhibitor of calcification of soft tissues. Mutations in ABCC6 that cause a loss of function result in decreased levels of circulating PPi, which leads to progressive calcification of elastic fibers in the skin, eyes, and cardiovascular system. This disease is known as Pseudoxanthoma elasticum (PXE).

Alternative Names

ABCC6; Human ABCC6

Background

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene.

Anti-ABCC6 rAb Products

Our recombinant anti-ABCC6 antibodies have been engineered to have high specificity and sensitivity for this key liver transporter, and can be used to reliably detect ABCC6 expression. We have validated these antibodies for demanding applications like IHC on liver biopsies and Western blotting of membrane preparations so you can have confidence in their performance. Creative Biolabs' rAbs will help you to explore the molecular underpinnings of PXE and assess novel therapeutics.

Table 1. Featured anti-ABCC6 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs is committed to helping accelerate the fight against rare metabolic diseases. We produce all of our recombinant antibodies on cutting-edge production platforms. The anti-ABCC6 recombinant antibodies are expressed in proprietary mammalian systems that have been optimized to produce antibodies that recognize the native, post-translationally modified structure of a target like the transmembrane transporter ABCC6. This focus on quality and fidelity guarantees that the products you receive from Creative Biolabs will have high biological relevance.

Featured Anti-ABCC6 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-ABCC6 recombinant antibody production.

Fig.2 Gram-scale anti-ABCC6 recombinant antibody production.

rAb Modalities

Creative Biolabs is passionate about supporting the rare disease community. Our anti-ABCC6 recombinant antibodies are offered in a range of modalities so you can pick the antibody format that is most suited to your experiments. We are also happy to customize orders based on your experimental requirements, so you can have confidence knowing that Creative Biolabs has the tools and experience you need to pursue research into the molecular basis of ectopic calcification and novel therapeutics for this disease.

Fig.3 Full-length anti-ABCC6 recombinant antibody production and modalities.

Discover the mechanisms underlying Pseudoxanthoma elasticum with Creative Biolabs' recombinant antibodies to ABCC6, the transporter that is deficient in this condition. Our extensive portfolio of rigorously validated and consistent reagents will help you to delve deeper into your research of this critical transporter and the diseases that are caused by its absence. Choose Creative Biolabs for quality you can trust.