Anti-ABCG5 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is proud to support the important field of hepatobiliary and metabolic disease research with our premier line of anti-ABCG5 recombinant antibodies. The ATP-binding cassette subfamily G member 5 (ABCG5) protein is half of an obligate heterodimeric sterol transporter that is uniquely expressed in the liver and intestine and plays an integral role in maintaining whole-body cholesterol homeostasis. Our top-notch ABCG5 antibodies have been expertly validated for their applications as reagents to study the biology of sitosterolemia, gallstone disease, and the regulation of intestinal cholesterol absorption and hepatic cholesterol excretion.

ABCG5: A Gatekeeper of Biliary and Intestinal Sterol Excretion

ABCG5 is a sterol transporter that forms an obligate heterodimer with its only partner protein, ABCG8, in the apical membrane of hepatocytes and enterocytes. In the liver, the ABCG5/G8 heterodimer pumps cholesterol from the liver cells into bile canaliculi, making biliary excretion the major pathway for the elimination of excess cholesterol from the body. In the intestine, ABCG5/G8 limits cholesterol and dietary plant sterol (e.g., sitosterol) absorption by pumping unabsorbed cholesterol and these sterols back into the intestinal lumen. Loss-of-function mutations in either ABCG5 or ABCG8 lead to sitosterolemia, a rare genetic disease characterized by increased sterol absorption from the intestine and premature atherosclerosis.

Alternative Names

ATP Binding Cassette Subfamily G Member 5; ATP-Binding Cassette, Sub-Family G (WHITE), Member 5; Sterolin 1; ATP-Binding Cassette Sub-Family G Member 5; Sterolin-1; STSL

Background

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia.

Anti-ABCG5 rAb Products

Creative Biolabs' anti-ABCG5 recombinant antibodies are designed to exclusively recognize and detect the ABCG5 protein, and have been rigorously validated to have no cross-reactivity with its obligate partner, ABCG8, or other ATP-binding cassette transporters. These features make this antibody ideal for studies into the expression and regulation of this critical sterol transporter. Optimized for IHC and Western Blot, this rAb is a proven tool for your metabolic disease research.

Table 1. Featured anti-ABCG5 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs is at the forefront of recombinant antibody technology, with next-generation production platforms that support and drive innovation in your exciting field of metabolic disease research. Our anti-ABCG5 recombinant antibodies are expressed in optimized mammalian systems to ensure they recognize the native, extracellular domains of ABCG5, providing a product with the greatest biological relevance.

Featured Anti-ABCG5 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-ABCG5 recombinant antibody production.

Fig.2 Gram-scale anti-ABCG5 recombinant antibody production.

rAb Modalities

Creative Biolabs helps power your research by providing a full line of antibodies with a variety of modalities to fit your research needs. Our anti-ABCG5 recombinant antibodies are available in a number of customizable formats, giving you the freedom to choose the right tool for your unique application. Empower the study of this key gatekeeper of cholesterol homeostasis with Creative Biolabs.

Fig.3 Full-length anti-ABCG5 recombinant antibody production and modalities.

Unlock the secrets of sterol transport with Creative Biolabs' anti-ABCG5 recombinant antibodies. Experience the rigorously validated and consistent performance our portfolio has to offer for your research in sitosterolemia, atherosclerosis, and gallstone disease. Partner with us to advance your work with quality that you can depend on. Connect with our specialists today.