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ACR
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- Mouse Anti-ACR Recombinant Antibody (clone 10F9) (MOB-1572z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC, ICC, IF
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For Research Use Only. Not For Clinical Use.
Background
Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids.
Protein class
Enzymes
Predicted location
Secreted
Single cell type specificity
Group enriched (Early spermatids, Spermatocytes, Late spermatids)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Not detected
Interaction
Heavy chain (catalytic) and a light chain linked by two disulfide bonds. Forms a heterodimer with SERPINA5.
Molecular function
Hydrolase, Protease, Serine protease
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