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ADAR
Anti-ADAR Recombinant Antibody Products
- Rabbit Anti-ADAR Recombinant Antibody (clone JU99-33) (MRO-0032-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IHC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, λ
- Application: WB, IP, IF, ELISA
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For Research Use Only. Not For Clinical Use.
This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants.
Protein class
Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homodimer. Homodimerization is essential for its catalytic activity (PubMed:12618436). Isoform 5 can form heterodimers with ADARB1/ADAR2. Isoform 1 interacts with ILF2/NF45 and ILF3/NF90 (PubMed:16055709). Binding to ILF3/NF90 up-regulates ILF3-mediated gene expression. Isoform 1 and isoform 5 (via DRBM 3 domain) interact with TNPO1 (PubMed:19124606, PubMed:24753571). Isoform 5 (via DRBM domains) interacts with XPO5 (PubMed:19124606). Isoform 1 and isoform 5 can interact with EIF2AK2/PKR and UPF1 (PubMed:17079286, PubMed:18362360).
Molecular function
DNA-binding, Hydrolase, RNA-binding
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