ADD3

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For Research Use Only. Not For Clinical Use.


Background

Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues.
Protein class

Disease related genes, Human disease related genes

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Astrocytes)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (ASC diff, ASC TERT1)

Interaction

Heterodimer of an alpha and a gamma subunit.

Molecular function

Actin-binding, Calmodulin-binding

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