AGMO

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For Research Use Only. Not For Clinical Use.


Background

The protein encoded by this gene is a tetrahydrobiopterin- and iron-dependent enzyme that cleaves the ether bond of alkylglycerols. Sequence comparisons distinguish this protein as forming a third, distinct class of tetrahydrobiopterin-dependent enzymes. Variations in this gene have been associated with decreased glucose-stimulated insulin response, type 2 diabetes, and susceptibility to intracranial aneurysms.
Protein class

Enzymes

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Hepatocytes, Oligodendrocytes, Oligodendrocyte precursor cells, Proximal enterocytes, Proximal tubular cells)

Immune cell specificity

Immune cell enhanced (basophil)

Cell line specificity

Cell line enhanced (HSkMC, Karpas-707, NTERA-2, SCLC-21H, TIME, WM-115)

Molecular function

Oxidoreductase

More Types Infomation
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