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AHCYL1
Anti-AHCYL1 Recombinant Antibody Products
- AbPlus™ Anti-AHCYL1 Magnetic Beads (VS-0724-YC1273) (VS-0724-YC1273)
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- Target: AHCYL1
- Target Species: Human
- Application: IP, Protein Purification
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- Anti-AHCYL1 Immunohistochemistry Kit (VS-0325-XY63)
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- Species Reactivity: Human, Mouse, Rat
- Target: AHCYL1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Protein class
Metabolic proteins, Transporters
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Astrocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Forms multimers (PubMed:16793548). Forms heteromultimers with AHCYL2 (via the C-terminal region) (PubMed:19220705). Interacts (when phosphorylated) with ITPR1 (when not phosphorylated); the interaction suppresses inositol 1,4,5-trisphosphate binding to ITPR1 (PubMed:16793548, PubMed:27995898). Interacts with BCL2L10; this strengthens the interaction of AHCYL1 with ITPR1 (PubMed:27995898). Interacts with CFTR and SLC26A6; the interactions take place once AHCYL1 is released from ITPR1 and increase CFTR and SLC26A6 activities (By similarity). Interacts with RRM1; in a phosphorylation- and (dATP)-dependent manner. Interacts (via PEST domain when phosphorylated) with SLC4A4 isoform 1 but not isoform 2; the interaction increases SLC4A4 isoform 1 activity (PubMed:16769890). Interacts (when phosphorylated) with SLC9A3; the interaction is required for SLC9A3 apical location and activity (PubMed:18829453, PubMed:20584908). Interacts (when phosphorylated) with FIP1L1; the interaction is direct and associates AHCYL1 with the CPSF complex and RNA (PubMed:19224921). Interacts with PAPOLA (PubMed:19224921). Interacts with ZCCHC4 (PubMed:31799605).
Molecular function
RNA-binding
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