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ALAS2

Anti-ALAS2 Products

Mouse Anti-ALAS2 Recombinant Antibody (clone CBLS-090) (MOB-0578MZ)
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: ELISA, WB
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Mouse Anti-ALAS2 Recombinant Antibody (clone 12-D) (VS3-QX37)
- Derivation: Mouse
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG1
- Application: WB, IP, IF, IHC
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Recombinant Rabbit Anti-ALAS2 Antibody (clone R06-3A3) (VS3-FY59)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IP
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Hi-Affi™ Rabbit Anti-ALAS2 Recombinant Antibody (clone DS131AB) (MOR-0131)
- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: Rabbit IgG
- Application: WB, FC, IP
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For Research Use Only. Not For Clinical Use.

The product of this gene specifies an erythroid-specific mitochondrially located enzyme. The encoded protein catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified.

Protein class

Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets

Predicted location

Intracellular

Single cell type specificity

Cell type enriched (Erythroid cells)

Immune cell specificity

Immune cell enriched (plasmacytoid DC)

Cell line specificity

Group enriched (HEL, K-562)

Interaction

Homodimer (PubMed:32499479). Interacts with SUCLA2 (PubMed:14643893, PubMed:32499479). [Isoform 4]: Interacts with SUCLA2.

Molecular function

Acyltransferase, Transferase

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