Anti-ALAS2 Recombinant Antibody Products

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Anti-ALAS2 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs delivers premium ALAS2-targeting recombinant antibodies to accelerate biomedical breakthroughs. Our advanced development platforms guarantee rigorously validated products with consistent performance across applications. Beyond supplying high-specificity reagents, we provide end-to-end technical support—from experimental design to data interpretation—ensuring research success. Researchers benefit from our tailored antibody solutions backed by two decades of protein engineering expertise, making us a trusted partner for advancing scientific discovery across therapeutic and diagnostic development.

ALAS2: A Key Player in Hematological Systemic Disorders and Therapeutic Targets

ALAS2, the erythroid-specific heme biosynthesis enzyme, plays a pivotal role in hematological and systemic disorders. As the rate-limiting catalyst in erythroid cell heme production, its dysfunction directly causes X-linked sideroblastic anemia through impaired hemoglobinization, resulting in microcytic anemia with pathological iron accumulation in mitochondria. Beyond hematopoiesis, disrupted activity contributes to porphyria phenotypes due to toxic porphyrin precursor accumulation, manifesting as severe photosensitivity and neurological complications. Emerging evidence links its metabolic byproducts to vascular pathologies, where excess protoporphyrins may induce endothelial dysfunction and platelet hyperactivity, exacerbating thrombotic risks. In myelodysplastic syndromes, somatic mutations correlate with refractory anemia and leukemic transformation, suggesting broader oncogenic implications. The enzyme's tissue specificity makes it a biomarker for erythroid malignancies, while its metabolic products influence systemic iron homeostasis – elevated erythroid protoporphyrins disrupt hepatic iron regulation, potentially worsening comorbidities in hereditary hemochromatosis. Therapeutic strategies targeting this pathway include pyridoxine supplementation for certain sideroblastic anemias and investigational heme analogs to bypass metabolic blocks. Recent studies also explore its role in modifying tumor microenvironments through heme-dependent oxygen sensing pathways, revealing potential cross-talk with HIF signaling in cancers. This multifaceted impact on erythropoiesis, iron metabolism, and systemic disease underscores its importance as both a diagnostic marker and therapeutic target.

Alternative Names

Complement ALAS-E; ALASE; ANH1; ASB; SIDBA1; XLDPP; XLEPP; XLSA

Background

The product of this gene specifies an erythroid-specific mitochondrially located enzyme. The encoded protein catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified.

Anti-ALAS2 rAb Products

We are dedicated to accelerating research and innovation by providing premium anti-ALAS2 recombinant antibody products that combine superior quality, exceptional cost-effectiveness, and unparalleled technical support.

Table 1. Featured anti-ALAS2 recombinant antibody products at Creative Biolabs.

Creative Quality Control

We accelerate biopharmaceutical innovation from discovery to market by embedding quality-first principles across our operations. Our certified quality management system ensures consistently reliable products that not only fulfill but anticipate research needs, enabling faster therapeutic development cycles. Through this proactive approach, we help partners overcome common bottlenecks in preclinical and clinical stages—delivering time savings while maintaining uncompromised scientific rigor throughout the commercialization journey.

Customer Reviews

Excellent

Si**s
Recombinant Rabbit Anti-ALAS2 Antibody (clone R06-3A3) (CAT#: VS3-FY59)

The Recombinant Rabbit Anti-ALAS2 works reliably in WB for detecting endogenous protein in K562 erythroleukemia cells and human bone marrow samples. It produces clean bands with minimal background when using 5% non-fat milk blocking. While it shows good specificity in erythroid lineages, weaker signals may require optimization in non-hematopoietic tissues. The antibody performs consistently across multiple lots, making it suitable for longitudinal studies of erythropoiesis and sideroblastic anemia research.

08/Apr/2024

Excellent

Ca**r
Mouse Anti-ALAS2 Recombinant Antibody (clone CBLS-090) (CAT#: MOB-0578MZ)

Mouse Anti-ALAS2 performs well in ELISA for quantifying recombinant ALAS2 protein, showing linear detection between 0.1-10 ng/mL. Tested with human spleen and fetal liver lysates, it demonstrates good specificity with minimal cross-reactivity to ALAS1. The antibody works reliably at 1:2000 dilution in sandwich ELISA formats. While suitable for quantitative assays, users should note it's not optimized for Western blot applications. Consistent lot-to-lot performance observed.

20/Aug/2024

Excellent

C**ss
Mouse Anti-ALAS2 Recombinant Antibody (clone 12-D) (CAT#: VS3-QX37)

This Mouse Anti-ALAS2 Recombinant Antibody worked well in IF on HEK293 cells. Showed specific staining without much background. Also tried on mouse liver tissue with good results. Easy to use, consistent performance. Good for detecting ALAS2 in different samples.

11/Jan/2023

rAb Production

With years of accumulated expertise in recombinant antibody development and optimization, we deliver superior-quality recombinant antibody products of the highest standards through top-tier services—all within the shortest possible timeframe.

Featured Anti-ALAS2 Recombinant Antibody Production Platforms
Fig.2 Milligram-scale recombinant antibody production.

Fig.3 Gram-scale recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to providing researchers with the most comprehensive and advanced high-quality recombinant antibodies in multiple formats. Our expertise in recombinant antibodies covers a diverse array of engineering methods. Complementing our products, we offer exceptional custom engineering services designed to meet your unique requirements.

Fig.4 Full Length Anti-ALAS2 Recombinant Antibody Production and Modalities.

If you need any further information about target ALAS2, please do not hesitate to contact us by phone or email. Our expert team is more than willing to assist you in resolving any questions or obstacles that may occur during your experiments, ensuring you receive the comprehensive support needed for successful research.