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ALOX5AP

This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Protein class

Disease related genes

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (dendritic cells, Macrophages, granulocytes, Hofbauer cells, T-cells, Langerhans cells, NK-cells)

Immune cell specificity

Group enriched (basophil, neutrophil, eosinophil, plasmacytoid DC)

Cell line specificity

Cell line enhanced (HDLM-2, HL-60, HMC-1, THP-1, U-937)

Interaction

Homotrimer. Interacts with LTC4S and ALOX5.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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