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ANKLE2
This gene encodes a member of the LEM family of inner nuclear membrane proteins. The encoded protein functions as a mitotic regulator through postmitotic formation of the nuclear envelope. Mutations in this gene cause morphology defects in the nuclear envelope and BAF hyperphosphorylation.
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Spermatocytes, Urothelial cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with BAF/BANF1. Interacts with protein phosphatase 2A (PP2A) components PPP2C (PPP2CA or PPP2CB) and PPP2R1A. (Microbial infection) May interact with non-structural protein 4A/NS4A from Zika virus strains Mr-766 or French Polynesia 10087PF/2013; the interaction may inhibit ANKLE2 function and contribute to defects in brain development, such as microcephaly.
More Types Infomation
- Recombinant Anti-Human ANKLE2 Antibody (MOB-3826z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: WB, Dot, FuncS
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- Recombinant Anti-Human ANKLE2 Antibody scFv Fragment (MOB-3826z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: IF, FC, Biosensors, FuncS
Compare
- Recombinant Anti-Human ANKLE2 Antibody Fab Fragment (MOB-3826z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: ELISA, FacS, FuncS
Compare
More Infomation
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For Research Use Only. Not For Clinical Use.