Anti-ANTXR2 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is a recognized name for infectious disease and oncology research and is dedicated to helping you discover and develop the best high quality anti-ANTXR2 recombinant antibodies for your research. Anthrax Toxin Receptor 2 (ANTXR2), also known as Capillary Morphogenesis Gene 2 (CMG2), has a well-established role in anthrax pathogenesis, but it is also a key player in angiogenesis. We have the validated antibodies you need to study its role as a receptor for anthrax toxins, as well as its role as a putative anti-angiogenic target for cancer.

ANTXR2: A Dual-Role Protein in Anthrax Pathogenesis and Angiogenesis

ANTXR2, also known as CMG2, is a transmembrane protein that has been best characterized as the receptor through which anthrax toxins enter host cells during infection. However, it also has well-established roles in a variety of normal physiological processes, most notably angiogenesis, or blood vessel formation. It binds to extracellular matrix components including collagen IV and laminin, and because of its high expression in tumor vasculature, it has been explored as a target for anti-cancer therapies, in an attempt to "starve" the tumor.

Alternative Names

Anthrax Toxin Receptor 2; Capillary Morphogenesis Gene 2 Protein; Capillary Morphogenesis Protein 2; CMG-2; CMG2; HFS; ISH; JHF

Background

This gene encodes a receptor for anthrax toxin. The protein binds to collagen IV and laminin, suggesting that it may be involved in extracellular matrix adhesion. Mutations in this gene cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Multiple transcript variants encoding different isoforms have been found for this gene.

Anti-ANTXR2 rAb Products

Our anti-ANTXR2 recombinant antibodies are designed with superior specificity and high affinity in mind. They are validated to differentiate between ANTXR2 and its homolog ANTXR1 so that you can be confident you are getting the right data every time. Use our rAbs to study toxin binding and internalization, or to evaluate expression on tumor tissues, with the accuracy you need to power your research.

Table 1. Featured anti-ANTXR2 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

At Creative Biolabs, we understand the unique needs of infectious disease and cancer researchers and leverage the most advanced antibody production platforms to fulfill them. We express our anti-ANTXR2 recombinant antibodies in optimized mammalian cell expression systems to produce fully functional antibodies with the correct folding and glycosylation.

Featured Anti-ANTXR2 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-ANTXR2 recombinant antibody production.

Fig.2 Gram-scale anti-ANTXR2 recombinant antibody production.

rAb Modalities

Creative Biolabs offers a wide variety of anti-ANTXR2 recombinant antibody modalities to suit your needs. We also provide customization services to produce the format that is most useful for your research, such as full-length IgGs for in vivo blocking studies, Fab fragments for structural studies, or antibody-drug conjugate (ADC) services to develop ADCs, empowering researchers around the world to explore this receptor with speed and efficiency.

Fig.3 Full-length anti-ANTXR2 recombinant antibody production and modalities.

ANTXR2-Targeted Drug Information

Table 2. Public drug targeting ANTXR2.

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Partner with Creative Biolabs for the best high quality anti-ANTXR2 recombinant antibodies for your research. We understand the importance of studying this multifunctional receptor, and we have the validated antibodies you need to study its role in anthrax pathogenesis and its role as a putative anti-angiogenic target. Contact our experts today to learn more.