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This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants.
Protein class

Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Group enriched (Sertoli cells, Smooth muscle cells, Peritubular cells, Theca cells, Adipocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enriched (ASC diff)


Homodimer; disulfide-linked. Can heterodimerize with isoform 2 leading to reduced surface expression. Forms a heterodimer with AOC2.

Molecular function


More Types Infomation

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For Research Use Only. Not For Clinical Use.

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